Patterns in age-seroprevalence consistent with acquired immunity against Trypanosoma brucei in Serengeti lions.
Trypanosomes cause disease in humans and livestock throughout sub-Saharan Africa. Although various species show evidence of clinical tolerance to trypanosomes, until now there has been no evidence of acquired immunity to natural infections. We discovered a distinct peak and decrease in age prevalenc...
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| Language: | English |
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Public Library of Science (PLoS)
2008-01-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0000347&type=printable |
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| author | Sue Welburn Kim Picozzi Paul G Coleman Craig Packer |
| author_facet | Sue Welburn Kim Picozzi Paul G Coleman Craig Packer |
| author_sort | Sue Welburn |
| collection | DOAJ |
| description | Trypanosomes cause disease in humans and livestock throughout sub-Saharan Africa. Although various species show evidence of clinical tolerance to trypanosomes, until now there has been no evidence of acquired immunity to natural infections. We discovered a distinct peak and decrease in age prevalence of T. brucei s.l. infection in wild African lions that is consistent with being driven by an exposure-dependent increase in cross-immunity following infections with the more genetically diverse species, T. congolense sensu latu. The causative agent of human sleeping sickness, T. brucei rhodesiense, disappears by 6 years of age apparently in response to cross-immunity from other trypanosomes, including the non-pathogenic subspecies, T. brucei brucei. These findings may suggest novel pathways for vaccinations against trypanosomiasis despite the notoriously complex antigenic surface proteins in these parasites. |
| format | Article |
| id | doaj-art-af87f894c2904de4a997fcf44b16fc6d |
| institution | OA Journals |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-af87f894c2904de4a997fcf44b16fc6d2025-08-20T02:14:30ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352008-01-01212e34710.1371/journal.pntd.0000347Patterns in age-seroprevalence consistent with acquired immunity against Trypanosoma brucei in Serengeti lions.Sue WelburnKim PicozziPaul G ColemanCraig PackerTrypanosomes cause disease in humans and livestock throughout sub-Saharan Africa. Although various species show evidence of clinical tolerance to trypanosomes, until now there has been no evidence of acquired immunity to natural infections. We discovered a distinct peak and decrease in age prevalence of T. brucei s.l. infection in wild African lions that is consistent with being driven by an exposure-dependent increase in cross-immunity following infections with the more genetically diverse species, T. congolense sensu latu. The causative agent of human sleeping sickness, T. brucei rhodesiense, disappears by 6 years of age apparently in response to cross-immunity from other trypanosomes, including the non-pathogenic subspecies, T. brucei brucei. These findings may suggest novel pathways for vaccinations against trypanosomiasis despite the notoriously complex antigenic surface proteins in these parasites.https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0000347&type=printable |
| spellingShingle | Sue Welburn Kim Picozzi Paul G Coleman Craig Packer Patterns in age-seroprevalence consistent with acquired immunity against Trypanosoma brucei in Serengeti lions. PLoS Neglected Tropical Diseases |
| title | Patterns in age-seroprevalence consistent with acquired immunity against Trypanosoma brucei in Serengeti lions. |
| title_full | Patterns in age-seroprevalence consistent with acquired immunity against Trypanosoma brucei in Serengeti lions. |
| title_fullStr | Patterns in age-seroprevalence consistent with acquired immunity against Trypanosoma brucei in Serengeti lions. |
| title_full_unstemmed | Patterns in age-seroprevalence consistent with acquired immunity against Trypanosoma brucei in Serengeti lions. |
| title_short | Patterns in age-seroprevalence consistent with acquired immunity against Trypanosoma brucei in Serengeti lions. |
| title_sort | patterns in age seroprevalence consistent with acquired immunity against trypanosoma brucei in serengeti lions |
| url | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0000347&type=printable |
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