Spindle epithelial tumor with thymus-like elements (SETTLE): a surgical case diagnosed preoperatively using fine-needle aspiration cytology
Spindle epithelial tumor with thymic-like elements (SETTLE) is an extremely rare tumor that occurs primarily in the thyroid gland. Histologically, SETTLE is characterized by the presence of spindle-shaped epithelial cells and glandular structures. However, it is known that diagnosis via fine-needle...
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Bioscientifica
2025-05-01
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| Series: | Endocrinology, Diabetes & Metabolism Case Reports |
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| author | Fumiaki Kawano Teru Chiyotanda Kazuhiko Nakame Satoru Meiri Tsuyoshi Fukushima Kousei Shirahama Yuichiro Sato Hideki Yamaguchi Makoto Ikenoue Shun Munakata Kazuhiro Higuchi Shinsuke Takeno Atsushi Nanashima |
| author_facet | Fumiaki Kawano Teru Chiyotanda Kazuhiko Nakame Satoru Meiri Tsuyoshi Fukushima Kousei Shirahama Yuichiro Sato Hideki Yamaguchi Makoto Ikenoue Shun Munakata Kazuhiro Higuchi Shinsuke Takeno Atsushi Nanashima |
| author_sort | Fumiaki Kawano |
| collection | DOAJ |
| description | Spindle epithelial tumor with thymic-like elements (SETTLE) is an extremely rare tumor that occurs primarily in the thyroid gland. Histologically, SETTLE is characterized by the presence of spindle-shaped epithelial cells and glandular structures. However, it is known that diagnosis via fine-needle aspiration cytology can be challenging. SETTLE predominantly occurs in younger individuals and has a less favorable prognosis compared to differentiated thyroid carcinoma. Therefore, ensuring accurate diagnosis and appropriate treatment is crucial. We encountered a case of spindle epithelial tumor with thymus-like differentiation in a 10-year-old patient for whom the preoperative diagnosis was successfully established through fine-needle aspiration cytology, which facilitated appropriate surgical resection. Comprehensive histopathological examination and immunohistochemical analysis are essential to ensure appropriate management and surveillance of SETTLE. |
| format | Article |
| id | doaj-art-af8614b436854c2a8d24b27d10f5f1cd |
| institution | OA Journals |
| issn | 2052-0573 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism Case Reports |
| spelling | doaj-art-af8614b436854c2a8d24b27d10f5f1cd2025-08-20T01:52:15ZengBioscientificaEndocrinology, Diabetes & Metabolism Case Reports2052-05732025-05-012025210.1530/EDM-25-00141Spindle epithelial tumor with thymus-like elements (SETTLE): a surgical case diagnosed preoperatively using fine-needle aspiration cytologyFumiaki Kawano0Teru Chiyotanda1Kazuhiko Nakame2Satoru Meiri3Tsuyoshi Fukushima4Kousei Shirahama5Yuichiro Sato6Hideki Yamaguchi7Makoto Ikenoue8Shun Munakata9Kazuhiro Higuchi10Shinsuke Takeno11Atsushi Nanashima12Department of Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, JapanDepartment of Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, JapanDepartment of Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, JapanDepartment of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki, JapanSection of Oncopathology and Morphological Pathology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, JapanDepartment of Diagnostic Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, JapanSection of Oncopathology and Morphological Pathology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, JapanDepartment of Diagnostic Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, JapanDepartment of Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, JapanDepartment of Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, JapanDepartment of Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, JapanDepartment of Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, JapanDepartment of Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, JapanSpindle epithelial tumor with thymic-like elements (SETTLE) is an extremely rare tumor that occurs primarily in the thyroid gland. Histologically, SETTLE is characterized by the presence of spindle-shaped epithelial cells and glandular structures. However, it is known that diagnosis via fine-needle aspiration cytology can be challenging. SETTLE predominantly occurs in younger individuals and has a less favorable prognosis compared to differentiated thyroid carcinoma. Therefore, ensuring accurate diagnosis and appropriate treatment is crucial. We encountered a case of spindle epithelial tumor with thymus-like differentiation in a 10-year-old patient for whom the preoperative diagnosis was successfully established through fine-needle aspiration cytology, which facilitated appropriate surgical resection. Comprehensive histopathological examination and immunohistochemical analysis are essential to ensure appropriate management and surveillance of SETTLE.https://edm.bioscientifica.com/view/journals/edm/2025/2/EDM-25-0014.xmlspindle epithelial tumor with thymus-like elements (settle)thyroidfine-needle aspiration cytology |
| spellingShingle | Fumiaki Kawano Teru Chiyotanda Kazuhiko Nakame Satoru Meiri Tsuyoshi Fukushima Kousei Shirahama Yuichiro Sato Hideki Yamaguchi Makoto Ikenoue Shun Munakata Kazuhiro Higuchi Shinsuke Takeno Atsushi Nanashima Spindle epithelial tumor with thymus-like elements (SETTLE): a surgical case diagnosed preoperatively using fine-needle aspiration cytology Endocrinology, Diabetes & Metabolism Case Reports spindle epithelial tumor with thymus-like elements (settle) thyroid fine-needle aspiration cytology |
| title | Spindle epithelial tumor with thymus-like elements (SETTLE): a surgical case diagnosed preoperatively using fine-needle aspiration cytology |
| title_full | Spindle epithelial tumor with thymus-like elements (SETTLE): a surgical case diagnosed preoperatively using fine-needle aspiration cytology |
| title_fullStr | Spindle epithelial tumor with thymus-like elements (SETTLE): a surgical case diagnosed preoperatively using fine-needle aspiration cytology |
| title_full_unstemmed | Spindle epithelial tumor with thymus-like elements (SETTLE): a surgical case diagnosed preoperatively using fine-needle aspiration cytology |
| title_short | Spindle epithelial tumor with thymus-like elements (SETTLE): a surgical case diagnosed preoperatively using fine-needle aspiration cytology |
| title_sort | spindle epithelial tumor with thymus like elements settle a surgical case diagnosed preoperatively using fine needle aspiration cytology |
| topic | spindle epithelial tumor with thymus-like elements (settle) thyroid fine-needle aspiration cytology |
| url | https://edm.bioscientifica.com/view/journals/edm/2025/2/EDM-25-0014.xml |
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