Supplementation of Arjun (Terminalia arjuna) bark powder prevented oxidative stress and enhanced antioxidants in kidneys on isoproterenol-treated Swiss albino mice model
Summary: This study aimed to investigate the impact of Arjun on the oxidative stress levels in the renal system. Oxidative stress induces renal injury, resulting in a range of problems including renal damage, renal dysfunction, and chronic kidney disease. The objective of this study was to investiga...
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| Language: | English |
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Elsevier
2025-04-01
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| Series: | Clinical Nutrition Open Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667268525000130 |
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| author | Rashedul Haque Sajib Paul Md. Tipu Sultan Faizul Islam Chowdhury Md. Kawser Shariful Islam Nayan S.M. Hafiz Hassan Afsana Kabir Chowdhury Raiyana Huda Sauda Sumaya Dina Sheikh Zahir Raihan |
| author_facet | Rashedul Haque Sajib Paul Md. Tipu Sultan Faizul Islam Chowdhury Md. Kawser Shariful Islam Nayan S.M. Hafiz Hassan Afsana Kabir Chowdhury Raiyana Huda Sauda Sumaya Dina Sheikh Zahir Raihan |
| author_sort | Rashedul Haque |
| collection | DOAJ |
| description | Summary: This study aimed to investigate the impact of Arjun on the oxidative stress levels in the renal system. Oxidative stress induces renal injury, resulting in a range of problems including renal damage, renal dysfunction, and chronic kidney disease. The objective of this study was to investigate the antioxidant properties and efficacy of Arjun in mitigating oxidative stress and renal damage induced by isoproterenol. A total of twenty-four mice were divided into four groups, with each group consisting of six mice. The body weight of each mouse in the groups was recorded daily. The weight of the organ, such as the kidney, while it was wet, was also recorded. Plasma levels of creatinine and uric acid were assessed using biochemical analysis. Plasma and kidney samples were analyzed to assess MDA, NO, and MPO levels as indicators of oxidative stress. Creatinine plasma (ISO- 1.6043 mg/dL, ISO + Arjun 2.5%- 1.4124 mg/dL, P = 0.0081) and in uric acid plasma (ISO- 3.2201, ISO + Arjun 2.5%- 2.8033, P = 0.0057). MDA plasma (ISO- 7.9600 nmol/mL, ISO + Arjun 2.5%- 5.0467 nmol/mL, P = 0.0070) and in MDA kidney (ISO- 29.7000 nmol/g tissue, ISO + Arjun 2.5%- 23.1667 nmol/g tissue, P = 0.0048). NO plasma (ISO- 9.5067 nmol/mL, ISO + Arjun 2.5%- 6.8800 nmol/mL, P = 0.0072) and in NO kidney (ISO- 192.2000 nmol/g tissue, ISO + Arjun 2.5%- 98.3667 nmol/g tissue, P = 0.0070). MPO plasma (ISO- 32.793 U/min/mL, ISO + Arjun 2.5%- 23.586 U/min/mL, P = 0.0041) and in MPO kidney (ISO- 121.950 U/min/mg protein, ISO + Arjun 2.5%- 79.492 U/min/mg protein, P = 0.0100). Catalase plasma (ISO- 15.90 U/min, ISO + Arjun 2.5%- 19.75 U/min, P = 0.0070) and in catalase kidney (ISO- 381.6 U/min/g protein, ISO + Arjun 2.5%- 581.9 U/min/g protein, P = 0.0082). SOD plasma (ISO- 22.667 U/min, ISO + Arjun 2.5%- 26.8000 U/min, P = 0.0080) and in SOD kidney (ISO- 60.9667 U/min/g protein, ISO + Arjun 2.5%- 91.1333 U/min/g protein, P = 0.0033). Ultimately, a histopathological examination was conducted on the kidney specimens, which were subjected to Hematoxylin and Eosin staining. Administration of isoproterenol led to cell infiltration in the kidney, while therapy with Arjun resulted in improved renal imaging. To summarize, it may be inferred that the antioxidant properties of Arjun mitigated the oxidative stress induced by isoproterenol in the kidney. |
| format | Article |
| id | doaj-art-af721cf6616b4eb1aee25125fac2f1d6 |
| institution | Kabale University |
| issn | 2667-2685 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Open Science |
| spelling | doaj-art-af721cf6616b4eb1aee25125fac2f1d62025-02-09T05:01:40ZengElsevierClinical Nutrition Open Science2667-26852025-04-01606677Supplementation of Arjun (Terminalia arjuna) bark powder prevented oxidative stress and enhanced antioxidants in kidneys on isoproterenol-treated Swiss albino mice modelRashedul Haque0Sajib Paul1Md. Tipu Sultan2Faizul Islam Chowdhury3Md. Kawser4Shariful Islam Nayan5S.M. Hafiz Hassan6Afsana Kabir Chowdhury7Raiyana Huda8Sauda Sumaya Dina9Sheikh Zahir Raihan10Department of Pharmacy, Dhaka International University, BangladeshDepartment of Pharmacy, Jagannath University, BangladeshDepartment of Pharmacy, Dhaka International University, BangladeshDepartment of Pharmacy, Dhaka International University, BangladeshDepartment of Pharmacy, Dhaka International University, BangladeshDepartment of Pharmaceutical Sciences, North South University, BangladeshDepartment of Pharmaceutical Sciences, North South University, BangladeshDepartment of Pharmacy, East West University, BangladeshDepartment of Pharmaceutical Sciences, North South University, BangladeshDepartment of Pharmacy, University of Asia Pacific, Bangladesh; Corresponding author. Department of Pharmacy, University of Asia Pacific, Bangladesh.Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Bangladesh; Corresponding author. Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Bangladesh.Summary: This study aimed to investigate the impact of Arjun on the oxidative stress levels in the renal system. Oxidative stress induces renal injury, resulting in a range of problems including renal damage, renal dysfunction, and chronic kidney disease. The objective of this study was to investigate the antioxidant properties and efficacy of Arjun in mitigating oxidative stress and renal damage induced by isoproterenol. A total of twenty-four mice were divided into four groups, with each group consisting of six mice. The body weight of each mouse in the groups was recorded daily. The weight of the organ, such as the kidney, while it was wet, was also recorded. Plasma levels of creatinine and uric acid were assessed using biochemical analysis. Plasma and kidney samples were analyzed to assess MDA, NO, and MPO levels as indicators of oxidative stress. Creatinine plasma (ISO- 1.6043 mg/dL, ISO + Arjun 2.5%- 1.4124 mg/dL, P = 0.0081) and in uric acid plasma (ISO- 3.2201, ISO + Arjun 2.5%- 2.8033, P = 0.0057). MDA plasma (ISO- 7.9600 nmol/mL, ISO + Arjun 2.5%- 5.0467 nmol/mL, P = 0.0070) and in MDA kidney (ISO- 29.7000 nmol/g tissue, ISO + Arjun 2.5%- 23.1667 nmol/g tissue, P = 0.0048). NO plasma (ISO- 9.5067 nmol/mL, ISO + Arjun 2.5%- 6.8800 nmol/mL, P = 0.0072) and in NO kidney (ISO- 192.2000 nmol/g tissue, ISO + Arjun 2.5%- 98.3667 nmol/g tissue, P = 0.0070). MPO plasma (ISO- 32.793 U/min/mL, ISO + Arjun 2.5%- 23.586 U/min/mL, P = 0.0041) and in MPO kidney (ISO- 121.950 U/min/mg protein, ISO + Arjun 2.5%- 79.492 U/min/mg protein, P = 0.0100). Catalase plasma (ISO- 15.90 U/min, ISO + Arjun 2.5%- 19.75 U/min, P = 0.0070) and in catalase kidney (ISO- 381.6 U/min/g protein, ISO + Arjun 2.5%- 581.9 U/min/g protein, P = 0.0082). SOD plasma (ISO- 22.667 U/min, ISO + Arjun 2.5%- 26.8000 U/min, P = 0.0080) and in SOD kidney (ISO- 60.9667 U/min/g protein, ISO + Arjun 2.5%- 91.1333 U/min/g protein, P = 0.0033). Ultimately, a histopathological examination was conducted on the kidney specimens, which were subjected to Hematoxylin and Eosin staining. Administration of isoproterenol led to cell infiltration in the kidney, while therapy with Arjun resulted in improved renal imaging. To summarize, it may be inferred that the antioxidant properties of Arjun mitigated the oxidative stress induced by isoproterenol in the kidney.http://www.sciencedirect.com/science/article/pii/S2667268525000130ArjunIsoproterenolAntioxidant enzyme activityCell infiltrationOxidative stress |
| spellingShingle | Rashedul Haque Sajib Paul Md. Tipu Sultan Faizul Islam Chowdhury Md. Kawser Shariful Islam Nayan S.M. Hafiz Hassan Afsana Kabir Chowdhury Raiyana Huda Sauda Sumaya Dina Sheikh Zahir Raihan Supplementation of Arjun (Terminalia arjuna) bark powder prevented oxidative stress and enhanced antioxidants in kidneys on isoproterenol-treated Swiss albino mice model Clinical Nutrition Open Science Arjun Isoproterenol Antioxidant enzyme activity Cell infiltration Oxidative stress |
| title | Supplementation of Arjun (Terminalia arjuna) bark powder prevented oxidative stress and enhanced antioxidants in kidneys on isoproterenol-treated Swiss albino mice model |
| title_full | Supplementation of Arjun (Terminalia arjuna) bark powder prevented oxidative stress and enhanced antioxidants in kidneys on isoproterenol-treated Swiss albino mice model |
| title_fullStr | Supplementation of Arjun (Terminalia arjuna) bark powder prevented oxidative stress and enhanced antioxidants in kidneys on isoproterenol-treated Swiss albino mice model |
| title_full_unstemmed | Supplementation of Arjun (Terminalia arjuna) bark powder prevented oxidative stress and enhanced antioxidants in kidneys on isoproterenol-treated Swiss albino mice model |
| title_short | Supplementation of Arjun (Terminalia arjuna) bark powder prevented oxidative stress and enhanced antioxidants in kidneys on isoproterenol-treated Swiss albino mice model |
| title_sort | supplementation of arjun terminalia arjuna bark powder prevented oxidative stress and enhanced antioxidants in kidneys on isoproterenol treated swiss albino mice model |
| topic | Arjun Isoproterenol Antioxidant enzyme activity Cell infiltration Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S2667268525000130 |
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