Accuracy of Longitudinal Assessment of Visceral Adipose Tissue by Dual-Energy X-Ray Absorptiometry in Children with Obesity
Background. Increased visceral adipose tissue (VAT) is strongly associated with cardiometabolic risk factors. Accurate quantification of VAT is available through magnetic resonance imaging (MRI), which incurs a significant financial and time burden. We aimed to assess the accuracy of dual-energy X-r...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2019/2193723 |
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| author | Katrin A. Dias Joyce S. Ramos Matthew P. Wallen Peter S. W. Davies Peter A. Cain Gary M. Leong Charlotte B. Ingul Jeff S. Coombes Shelley E. Keating |
| author_facet | Katrin A. Dias Joyce S. Ramos Matthew P. Wallen Peter S. W. Davies Peter A. Cain Gary M. Leong Charlotte B. Ingul Jeff S. Coombes Shelley E. Keating |
| author_sort | Katrin A. Dias |
| collection | DOAJ |
| description | Background. Increased visceral adipose tissue (VAT) is strongly associated with cardiometabolic risk factors. Accurate quantification of VAT is available through magnetic resonance imaging (MRI), which incurs a significant financial and time burden. We aimed to assess the accuracy of dual-energy X-ray absorptiometry- (DXA-) derived VAT (DXA-VAT) against a gold standard MRI protocol (MRI-VAT) in children with normal weight and obesity cross-sectionally, and over the course of a lifestyle intervention. Methodology. MRI-VAT and DXA-VAT were quantified in 61 children (30 normal weight and 31 with obesity) at baseline. Children with obesity entered a three-month exercise and/or nutrition intervention after which VAT was reassessed. MRI- and DXA-VAT cross-sectional area, volume, and mass were quantified, and associations were calculated at baseline (n = 61) and pre-post intervention (n = 28, 3 participants dropped out). Method agreement was assessed through Bland–Altman analysis, linear regression, and Passing–Bablok regression. Results. At baseline, all DXA- and MRI-VAT outcomes were strongly associated (r = 0.90, P<0.001). However, there were no significant associations between absolute or relative change in DXA- and MRI-VAT outcomes (r = 0.25–0.36, P>0.05). DXA significantly overestimated VAT CSA (cross-sectional area), volume, and mass when compared with MRI (P<0.001) at baseline. Significant proportional bias was observed for all DXA-VAT outcomes at baseline and for relative longitudinal changes in DXA-VAT. Conclusions. Although DXA-VAT outcomes were strongly associated with MRI-VAT outcomes at baseline, estimates were subject to proportional bias in children with obesity and normal weight. DXA lacks validity for detecting changes in VAT among children with obesity. This trial is registered with NCT01991106. |
| format | Article |
| id | doaj-art-af6936a4035e4988b8ff7dbd1ff193bd |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-af6936a4035e4988b8ff7dbd1ff193bd2025-08-20T03:39:05ZengWileyJournal of Obesity2090-07082090-07162019-01-01201910.1155/2019/21937232193723Accuracy of Longitudinal Assessment of Visceral Adipose Tissue by Dual-Energy X-Ray Absorptiometry in Children with ObesityKatrin A. Dias0Joyce S. Ramos1Matthew P. Wallen2Peter S. W. Davies3Peter A. Cain4Gary M. Leong5Charlotte B. Ingul6Jeff S. Coombes7Shelley E. Keating8School of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Brisbane, QLD, AustraliaSchool of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Brisbane, QLD, AustraliaSchool of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Brisbane, QLD, AustraliaChild Health Research Centre, The University of Queensland, Brisbane, QLD, AustraliaHeart Care Partners, The Wesley Hospital, Brisbane, QLD, AustraliaNepean Hospital and Nepean Charles Perkins Center Research Hub, University of Sydney, Kingswood, NSW, AustraliaDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, NorwaySchool of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Brisbane, QLD, AustraliaSchool of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Brisbane, QLD, AustraliaBackground. Increased visceral adipose tissue (VAT) is strongly associated with cardiometabolic risk factors. Accurate quantification of VAT is available through magnetic resonance imaging (MRI), which incurs a significant financial and time burden. We aimed to assess the accuracy of dual-energy X-ray absorptiometry- (DXA-) derived VAT (DXA-VAT) against a gold standard MRI protocol (MRI-VAT) in children with normal weight and obesity cross-sectionally, and over the course of a lifestyle intervention. Methodology. MRI-VAT and DXA-VAT were quantified in 61 children (30 normal weight and 31 with obesity) at baseline. Children with obesity entered a three-month exercise and/or nutrition intervention after which VAT was reassessed. MRI- and DXA-VAT cross-sectional area, volume, and mass were quantified, and associations were calculated at baseline (n = 61) and pre-post intervention (n = 28, 3 participants dropped out). Method agreement was assessed through Bland–Altman analysis, linear regression, and Passing–Bablok regression. Results. At baseline, all DXA- and MRI-VAT outcomes were strongly associated (r = 0.90, P<0.001). However, there were no significant associations between absolute or relative change in DXA- and MRI-VAT outcomes (r = 0.25–0.36, P>0.05). DXA significantly overestimated VAT CSA (cross-sectional area), volume, and mass when compared with MRI (P<0.001) at baseline. Significant proportional bias was observed for all DXA-VAT outcomes at baseline and for relative longitudinal changes in DXA-VAT. Conclusions. Although DXA-VAT outcomes were strongly associated with MRI-VAT outcomes at baseline, estimates were subject to proportional bias in children with obesity and normal weight. DXA lacks validity for detecting changes in VAT among children with obesity. This trial is registered with NCT01991106.http://dx.doi.org/10.1155/2019/2193723 |
| spellingShingle | Katrin A. Dias Joyce S. Ramos Matthew P. Wallen Peter S. W. Davies Peter A. Cain Gary M. Leong Charlotte B. Ingul Jeff S. Coombes Shelley E. Keating Accuracy of Longitudinal Assessment of Visceral Adipose Tissue by Dual-Energy X-Ray Absorptiometry in Children with Obesity Journal of Obesity |
| title | Accuracy of Longitudinal Assessment of Visceral Adipose Tissue by Dual-Energy X-Ray Absorptiometry in Children with Obesity |
| title_full | Accuracy of Longitudinal Assessment of Visceral Adipose Tissue by Dual-Energy X-Ray Absorptiometry in Children with Obesity |
| title_fullStr | Accuracy of Longitudinal Assessment of Visceral Adipose Tissue by Dual-Energy X-Ray Absorptiometry in Children with Obesity |
| title_full_unstemmed | Accuracy of Longitudinal Assessment of Visceral Adipose Tissue by Dual-Energy X-Ray Absorptiometry in Children with Obesity |
| title_short | Accuracy of Longitudinal Assessment of Visceral Adipose Tissue by Dual-Energy X-Ray Absorptiometry in Children with Obesity |
| title_sort | accuracy of longitudinal assessment of visceral adipose tissue by dual energy x ray absorptiometry in children with obesity |
| url | http://dx.doi.org/10.1155/2019/2193723 |
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