Sesquiterpenoids from <i>Dysoxylum amooroides</i> Stem Bark: Isolation, Structure Determination, and Cytotoxicity Against MCF-7 Breast Cancer Cells
Three sesquiterpenoids, guaianediol (1), alismol (2), and spathulenol (3), were isolated from the n-hexane and ethyl acetate extracts of the stem bark of Dysoxylum amooroides. The three compounds were found in D. amooroides species for the first time. The structures of the isolated compounds were id...
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Department of Chemistry, Universitas Gadjah Mada
2025-01-01
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| Series: | Indonesian Journal of Chemistry |
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| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/99121 |
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| author | Latifah Gunawan Hidayat Nurul Mustofa Al Arofatus Naini Desi Harneti Ace Tatang Hidayat Nurlelasari Nurlelasari Rani Maharani Tri Mayanti Sofa Fajriah Khalijah Awang Mohamad Nurul Azmi Unang Supratman |
| author_facet | Latifah Gunawan Hidayat Nurul Mustofa Al Arofatus Naini Desi Harneti Ace Tatang Hidayat Nurlelasari Nurlelasari Rani Maharani Tri Mayanti Sofa Fajriah Khalijah Awang Mohamad Nurul Azmi Unang Supratman |
| author_sort | Latifah Gunawan |
| collection | DOAJ |
| description | Three sesquiterpenoids, guaianediol (1), alismol (2), and spathulenol (3), were isolated from the n-hexane and ethyl acetate extracts of the stem bark of Dysoxylum amooroides. The three compounds were found in D. amooroides species for the first time. The structures of the isolated compounds were identified and established based on an extensive spectroscopic analysis involving HR-TOF-ESI-MS, IR, and NMR data, as well as a comparison with the previously reported works of literature. Compounds 1-3 were further assessed for cytotoxic effects against MCF-7 breast cancer cells. Guaianediol (1) showed inactive activity with IC50 > 100 µM, alismol (2) showed weak activity with IC50 value of 82.1 µM and spathulenol (3) showed considerable activity with an IC50 value of 15.2 µM. A brief structure-activity relationship and comparison with the previous works were also discussed to understand better the role of guaiane- and aromadendrane-type sesquiterpenoids in the biological activity perspective. |
| format | Article |
| id | doaj-art-af68bfcf8b1840a6a1f3da645cad854a |
| institution | Kabale University |
| issn | 1411-9420 2460-1578 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj-art-af68bfcf8b1840a6a1f3da645cad854a2025-02-03T04:32:43ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782025-01-0125115716810.22146/ijc.9912136770Sesquiterpenoids from <i>Dysoxylum amooroides</i> Stem Bark: Isolation, Structure Determination, and Cytotoxicity Against MCF-7 Breast Cancer CellsLatifah Gunawan0Hidayat Nurul Mustofa1Al Arofatus Naini2Desi Harneti3Ace Tatang Hidayat4Nurlelasari Nurlelasari5Rani Maharani6Tri Mayanti7Sofa Fajriah8Khalijah Awang9Mohamad Nurul Azmi10Unang Supratman11Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, IndonesiaResearch Center for Chemistry, National Research and Innovation Agency (BRIN), Jl. Kw. Puspiptek, Muncul, Kawasan PUSPIPTEK Serpong, Tangerang Selatan 15314, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia; Central Laboratory of Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, IndonesiaResearch Center for Chemistry, National Research and Innovation Agency (BRIN), Jl. Kw. Puspiptek, Muncul, Kawasan PUSPIPTEK Serpong, Tangerang Selatan 15314, IndonesiaDepartment of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, MalaysiaSchool of Chemical Sciences, Universiti Sains Malaysia, Minden, Penang 11800, MalaysiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia; Central Laboratory of Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, IndonesiaThree sesquiterpenoids, guaianediol (1), alismol (2), and spathulenol (3), were isolated from the n-hexane and ethyl acetate extracts of the stem bark of Dysoxylum amooroides. The three compounds were found in D. amooroides species for the first time. The structures of the isolated compounds were identified and established based on an extensive spectroscopic analysis involving HR-TOF-ESI-MS, IR, and NMR data, as well as a comparison with the previously reported works of literature. Compounds 1-3 were further assessed for cytotoxic effects against MCF-7 breast cancer cells. Guaianediol (1) showed inactive activity with IC50 > 100 µM, alismol (2) showed weak activity with IC50 value of 82.1 µM and spathulenol (3) showed considerable activity with an IC50 value of 15.2 µM. A brief structure-activity relationship and comparison with the previous works were also discussed to understand better the role of guaiane- and aromadendrane-type sesquiterpenoids in the biological activity perspective.https://jurnal.ugm.ac.id/ijc/article/view/99121cytotoxic activitydysoxylum amooroidesmcf-7sesquiterpenoids |
| spellingShingle | Latifah Gunawan Hidayat Nurul Mustofa Al Arofatus Naini Desi Harneti Ace Tatang Hidayat Nurlelasari Nurlelasari Rani Maharani Tri Mayanti Sofa Fajriah Khalijah Awang Mohamad Nurul Azmi Unang Supratman Sesquiterpenoids from <i>Dysoxylum amooroides</i> Stem Bark: Isolation, Structure Determination, and Cytotoxicity Against MCF-7 Breast Cancer Cells Indonesian Journal of Chemistry cytotoxic activity dysoxylum amooroides mcf-7 sesquiterpenoids |
| title | Sesquiterpenoids from <i>Dysoxylum amooroides</i> Stem Bark: Isolation, Structure Determination, and Cytotoxicity Against MCF-7 Breast Cancer Cells |
| title_full | Sesquiterpenoids from <i>Dysoxylum amooroides</i> Stem Bark: Isolation, Structure Determination, and Cytotoxicity Against MCF-7 Breast Cancer Cells |
| title_fullStr | Sesquiterpenoids from <i>Dysoxylum amooroides</i> Stem Bark: Isolation, Structure Determination, and Cytotoxicity Against MCF-7 Breast Cancer Cells |
| title_full_unstemmed | Sesquiterpenoids from <i>Dysoxylum amooroides</i> Stem Bark: Isolation, Structure Determination, and Cytotoxicity Against MCF-7 Breast Cancer Cells |
| title_short | Sesquiterpenoids from <i>Dysoxylum amooroides</i> Stem Bark: Isolation, Structure Determination, and Cytotoxicity Against MCF-7 Breast Cancer Cells |
| title_sort | sesquiterpenoids from i dysoxylum amooroides i stem bark isolation structure determination and cytotoxicity against mcf 7 breast cancer cells |
| topic | cytotoxic activity dysoxylum amooroides mcf-7 sesquiterpenoids |
| url | https://jurnal.ugm.ac.id/ijc/article/view/99121 |
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