Effect of physical activity on the risk of new-onset chronic kidney disease: a systematic review and meta-analysis of cohort studies
Abstract Objective The aim of this systematic review and meta-analysis was to investigate the association between physical activity levels and the risk of developing new-onset chronic kidney disease (CKD). Methods In accordance with PRISMA guidelines and PROSPERO registration, a detailed literature...
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Springer
2025-07-01
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| Series: | Discover Public Health |
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| Online Access: | https://doi.org/10.1186/s12982-025-00740-1 |
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| author | Arman Shafiee Fatemeh Movahed Masoud Dehbozorgi Sanam Mirzaei Ali Kolahdooz Saleheh Khorasani Farima Safari Saba Goodarzi Neda Izadi |
| author_facet | Arman Shafiee Fatemeh Movahed Masoud Dehbozorgi Sanam Mirzaei Ali Kolahdooz Saleheh Khorasani Farima Safari Saba Goodarzi Neda Izadi |
| author_sort | Arman Shafiee |
| collection | DOAJ |
| description | Abstract Objective The aim of this systematic review and meta-analysis was to investigate the association between physical activity levels and the risk of developing new-onset chronic kidney disease (CKD). Methods In accordance with PRISMA guidelines and PROSPERO registration, a detailed literature search was conducted in PubMed, Embase, Scopus, Cochrane and Web of Science databases until April 13, 2025. Meta-analysis was performed using random effect model, assessing heterogeneity and publication bias. Results Thirteen prospective cohort studies were included, with a pooled analysis showing a protective effect of low and moderate physical activity against CKD (hazard ratio= 0.91; 95% CI: 0.87–0.96). High levels of physical activity showed a stronger preventive effect (hazard ratio= 0.85; 95% CI: 0.79–0.92). The quality assessment of the studies indicates acceptable quality, with good results for selection and outcomes, but some shortcomings in comparability. No publication bias was found for either outcome. Conclusion The results of this study provide compelling evidence that physical activity, particularly at higher levels, significantly reduces the risk of new-onset CKD and alsoemphasize the importance of incorporating physical activity into public health strategies aimed at preventing chronic kidney disease. Given the stronger preventive effect observed with high levels of physical activity, the promotion and encouragement of individuals should be emphasized. However, heterogeneity in study designs and definitions of physical activity and CKD may limit the generalizability of these findings |
| format | Article |
| id | doaj-art-af636291cccd4f9cbba66ec12a0d3ba1 |
| institution | Kabale University |
| issn | 3005-0774 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Public Health |
| spelling | doaj-art-af636291cccd4f9cbba66ec12a0d3ba12025-08-20T03:45:22ZengSpringerDiscover Public Health3005-07742025-07-0122112810.1186/s12982-025-00740-1Effect of physical activity on the risk of new-onset chronic kidney disease: a systematic review and meta-analysis of cohort studiesArman Shafiee0Fatemeh Movahed1Masoud Dehbozorgi2Sanam Mirzaei3Ali Kolahdooz4Saleheh Khorasani5Farima Safari6Saba Goodarzi7Neda Izadi8Non-Communicable Diseases Research Center, Alborz University of Medical SciencesSchool of Medicine, Tehran University of Medical SciencesSchool of Medicine, RWTH Aachen UniversityStudent Research Committee, School of Medicine, Tabriz University of Medical SciencesStudent Research Committee, School of Medicine, Alborz University of Medical SciencesStudent Research Committee, School of Medicine, Alborz University of Medical SciencesStudent Research Committee, School of Medicine, Shiraz University of Medical SciencesStudent Research Committee, School of Medicine, Alborz University of Medical SciencesResearch Center for Social Determinants of Health, Research Institute for Metabolic and Obesity Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesAbstract Objective The aim of this systematic review and meta-analysis was to investigate the association between physical activity levels and the risk of developing new-onset chronic kidney disease (CKD). Methods In accordance with PRISMA guidelines and PROSPERO registration, a detailed literature search was conducted in PubMed, Embase, Scopus, Cochrane and Web of Science databases until April 13, 2025. Meta-analysis was performed using random effect model, assessing heterogeneity and publication bias. Results Thirteen prospective cohort studies were included, with a pooled analysis showing a protective effect of low and moderate physical activity against CKD (hazard ratio= 0.91; 95% CI: 0.87–0.96). High levels of physical activity showed a stronger preventive effect (hazard ratio= 0.85; 95% CI: 0.79–0.92). The quality assessment of the studies indicates acceptable quality, with good results for selection and outcomes, but some shortcomings in comparability. No publication bias was found for either outcome. Conclusion The results of this study provide compelling evidence that physical activity, particularly at higher levels, significantly reduces the risk of new-onset CKD and alsoemphasize the importance of incorporating physical activity into public health strategies aimed at preventing chronic kidney disease. Given the stronger preventive effect observed with high levels of physical activity, the promotion and encouragement of individuals should be emphasized. However, heterogeneity in study designs and definitions of physical activity and CKD may limit the generalizability of these findingshttps://doi.org/10.1186/s12982-025-00740-1Physical activityChronic kidney diseaseIncidenceSystematic reviewMeta-analysis |
| spellingShingle | Arman Shafiee Fatemeh Movahed Masoud Dehbozorgi Sanam Mirzaei Ali Kolahdooz Saleheh Khorasani Farima Safari Saba Goodarzi Neda Izadi Effect of physical activity on the risk of new-onset chronic kidney disease: a systematic review and meta-analysis of cohort studies Discover Public Health Physical activity Chronic kidney disease Incidence Systematic review Meta-analysis |
| title | Effect of physical activity on the risk of new-onset chronic kidney disease: a systematic review and meta-analysis of cohort studies |
| title_full | Effect of physical activity on the risk of new-onset chronic kidney disease: a systematic review and meta-analysis of cohort studies |
| title_fullStr | Effect of physical activity on the risk of new-onset chronic kidney disease: a systematic review and meta-analysis of cohort studies |
| title_full_unstemmed | Effect of physical activity on the risk of new-onset chronic kidney disease: a systematic review and meta-analysis of cohort studies |
| title_short | Effect of physical activity on the risk of new-onset chronic kidney disease: a systematic review and meta-analysis of cohort studies |
| title_sort | effect of physical activity on the risk of new onset chronic kidney disease a systematic review and meta analysis of cohort studies |
| topic | Physical activity Chronic kidney disease Incidence Systematic review Meta-analysis |
| url | https://doi.org/10.1186/s12982-025-00740-1 |
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