Analysis of Animal Models of Traumatic Osteonecrosis of the Femoral Head Based on Blood Supply: A Literature Review
ABSTRACT Traumatic osteonecrosis of the femoral head (TONFH) refers to ischemic osteonecrosis is resulting from an acute mechanical interruption of the blood supply to the femoral head. The early diagnosis and optimal treatment have been central focuses of research and continue to undergo improvemen...
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| Format: | Article |
| Language: | English |
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Wiley
2025-03-01
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| Series: | Orthopaedic Surgery |
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| Online Access: | https://doi.org/10.1111/os.14352 |
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| author | Linbao Wang Yunzhuan Luo Xing Qiu Liangliang Cheng Kaiming Ma Jianchen Guan Yuchen Liu Jiawei Ying Dewei Zhao |
| author_facet | Linbao Wang Yunzhuan Luo Xing Qiu Liangliang Cheng Kaiming Ma Jianchen Guan Yuchen Liu Jiawei Ying Dewei Zhao |
| author_sort | Linbao Wang |
| collection | DOAJ |
| description | ABSTRACT Traumatic osteonecrosis of the femoral head (TONFH) refers to ischemic osteonecrosis is resulting from an acute mechanical interruption of the blood supply to the femoral head. The early diagnosis and optimal treatment have been central focuses of research and continue to undergo improvement. Reliable animal models are essential for advancing research into the treatment of the disease. This review aims to provide a comprehensive overview of tetrapod models (rats, rabbits, dogs, and sheep) and bipod models (emus, ostriches), as well as various modeling methods (traumatic hip dislocation, dissection of the round ligament and ligature of the femoral neck, femoral neck fracture (FNF), reduction and internal fixation after femoral neck fracture, and highly selective disruption of the anterior‐superior retinacular vessels). This review examines the advantages, disadvantages, and applicability of each model. Based on blood flow analysis, it proposes a more reliable direction for TONFH modeling: simulating partial blood flow injury in the context of FNF. |
| format | Article |
| id | doaj-art-af5ec85e2a244a7da1b1a3b5f49d129a |
| institution | DOAJ |
| issn | 1757-7853 1757-7861 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Orthopaedic Surgery |
| spelling | doaj-art-af5ec85e2a244a7da1b1a3b5f49d129a2025-08-20T02:54:33ZengWileyOrthopaedic Surgery1757-78531757-78612025-03-0117370371310.1111/os.14352Analysis of Animal Models of Traumatic Osteonecrosis of the Femoral Head Based on Blood Supply: A Literature ReviewLinbao Wang0Yunzhuan Luo1Xing Qiu2Liangliang Cheng3Kaiming Ma4Jianchen Guan5Yuchen Liu6Jiawei Ying7Dewei Zhao8Department of Orthopaedic Affiliated ZhongShan Hospital of Dalian University Dalian ChinaDepartment of Orthopaedic Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou ChinaDepartment of Orthopaedic Affiliated ZhongShan Hospital of Dalian University Dalian ChinaDepartment of Orthopaedic Affiliated ZhongShan Hospital of Dalian University Dalian ChinaDepartment of Orthopaedic Affiliated ZhongShan Hospital of Dalian University Dalian ChinaDepartment of Orthopaedic Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou ChinaDepartment of Orthopaedic Affiliated ZhongShan Hospital of Dalian University Dalian ChinaDepartment of Orthopaedic Affiliated ZhongShan Hospital of Dalian University Dalian ChinaDepartment of Orthopaedic Affiliated ZhongShan Hospital of Dalian University Dalian ChinaABSTRACT Traumatic osteonecrosis of the femoral head (TONFH) refers to ischemic osteonecrosis is resulting from an acute mechanical interruption of the blood supply to the femoral head. The early diagnosis and optimal treatment have been central focuses of research and continue to undergo improvement. Reliable animal models are essential for advancing research into the treatment of the disease. This review aims to provide a comprehensive overview of tetrapod models (rats, rabbits, dogs, and sheep) and bipod models (emus, ostriches), as well as various modeling methods (traumatic hip dislocation, dissection of the round ligament and ligature of the femoral neck, femoral neck fracture (FNF), reduction and internal fixation after femoral neck fracture, and highly selective disruption of the anterior‐superior retinacular vessels). This review examines the advantages, disadvantages, and applicability of each model. Based on blood flow analysis, it proposes a more reliable direction for TONFH modeling: simulating partial blood flow injury in the context of FNF.https://doi.org/10.1111/os.14352animal modelfemoral neck fractureinflammatory responseretinacular vesselstraumatic osteonecrosis of the femoral head |
| spellingShingle | Linbao Wang Yunzhuan Luo Xing Qiu Liangliang Cheng Kaiming Ma Jianchen Guan Yuchen Liu Jiawei Ying Dewei Zhao Analysis of Animal Models of Traumatic Osteonecrosis of the Femoral Head Based on Blood Supply: A Literature Review Orthopaedic Surgery animal model femoral neck fracture inflammatory response retinacular vessels traumatic osteonecrosis of the femoral head |
| title | Analysis of Animal Models of Traumatic Osteonecrosis of the Femoral Head Based on Blood Supply: A Literature Review |
| title_full | Analysis of Animal Models of Traumatic Osteonecrosis of the Femoral Head Based on Blood Supply: A Literature Review |
| title_fullStr | Analysis of Animal Models of Traumatic Osteonecrosis of the Femoral Head Based on Blood Supply: A Literature Review |
| title_full_unstemmed | Analysis of Animal Models of Traumatic Osteonecrosis of the Femoral Head Based on Blood Supply: A Literature Review |
| title_short | Analysis of Animal Models of Traumatic Osteonecrosis of the Femoral Head Based on Blood Supply: A Literature Review |
| title_sort | analysis of animal models of traumatic osteonecrosis of the femoral head based on blood supply a literature review |
| topic | animal model femoral neck fracture inflammatory response retinacular vessels traumatic osteonecrosis of the femoral head |
| url | https://doi.org/10.1111/os.14352 |
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