The effect of swimming training on inflammatory cytokines in serum of mice infected depression-type 2 diabetes
Introduction: Clinical and experimental studies have shown that type 2 diabetes is associated with depression-related disorders. Inflammation has been identified as a common mechanism in both type 2 diabetes and depression. Several studies have suggested that swimming exercise might be able to reduc...
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Kurdistan University of Medical Scienses
2024-09-01
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| Series: | روانشناسی و روانپزشکی شناخت |
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| Online Access: | https://shenakht.muk.ac.ir/article-1-1948-en.html |
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| author | Mohadeseh Gilak dalasm Maghsoud Peeri Mohammad Ali Azarbaijani |
| author_facet | Mohadeseh Gilak dalasm Maghsoud Peeri Mohammad Ali Azarbaijani |
| author_sort | Mohadeseh Gilak dalasm |
| collection | DOAJ |
| description | Introduction: Clinical and experimental studies have shown that type 2 diabetes is associated with depression-related disorders. Inflammation has been identified as a common mechanism in both type 2 diabetes and depression. Several studies have suggested that swimming exercise might be able to reduce depression-related symptoms
Aim: The present research aims to investigate the effect of swimming training on inflammatory cytokines in the serum of rats with depression-type 2 diabetes.
Method: The experimental research design is a randomized controlled trial. The statistical population is male C57BL6 mice kept in Pasteur Institute of Iran in 2021. 40 mice were randomly selected and randomly divided into two groups (20 samples in each group). One group became diabetic with a high-fat diet and Streptozotocin. Diabetic samples underwent swimming training for 4 weeks. Then, depression-like behaviors were assessed with Sucrose preference, Novelty-suppressed feeding, Social interaction, and Tail suspension test. We also measured the levels of glucose, insulin and inflammatory cytokines such as IL-1β and TNF-α in the serum of the animals. The data were analyzed by Graphpad Primes.
Results: The results indicated that type 2 diabetes significantly increased anhedonia- and depression-like behaviours in mice. Moreover, swimming exercise reduced anhedonia- and depression-like behaviour in type 2 diabetic mice. Swimming exercise also decreased glucose and inflammatory cytokines in the serum of mice with type 2 diabetes.
Conclusion: Collectively, this study demonstrates that swimming exercise decreased depression-like behaviour by reducing inflammation in type 2 diabetic mice.Further clinical studies are needed to validate these findings in patients with type 2 diabetes. |
| format | Article |
| id | doaj-art-af59c13eb6ba4bc39e85cf7ef22e4f33 |
| institution | DOAJ |
| issn | 2588-6657 2476-2962 |
| language | fas |
| publishDate | 2024-09-01 |
| publisher | Kurdistan University of Medical Scienses |
| record_format | Article |
| series | روانشناسی و روانپزشکی شناخت |
| spelling | doaj-art-af59c13eb6ba4bc39e85cf7ef22e4f332025-08-20T03:10:51ZfasKurdistan University of Medical Sciensesروانشناسی و روانپزشکی شناخت2588-66572476-29622024-09-0111414916910.32598/shenakht.11.4.149The effect of swimming training on inflammatory cytokines in serum of mice infected depression-type 2 diabetesMohadeseh Gilak dalasm0https://orcid.org/0000-0000-0000-0000Maghsoud Peeri1https://orcid.org/0000-0000-0000-0000 Mohammad Ali Azarbaijani2https://orcid.org/0000-0000-0000-0000Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Central Tehran Branch, Islamic Azad University, Tehran, IranIntroduction: Clinical and experimental studies have shown that type 2 diabetes is associated with depression-related disorders. Inflammation has been identified as a common mechanism in both type 2 diabetes and depression. Several studies have suggested that swimming exercise might be able to reduce depression-related symptoms Aim: The present research aims to investigate the effect of swimming training on inflammatory cytokines in the serum of rats with depression-type 2 diabetes. Method: The experimental research design is a randomized controlled trial. The statistical population is male C57BL6 mice kept in Pasteur Institute of Iran in 2021. 40 mice were randomly selected and randomly divided into two groups (20 samples in each group). One group became diabetic with a high-fat diet and Streptozotocin. Diabetic samples underwent swimming training for 4 weeks. Then, depression-like behaviors were assessed with Sucrose preference, Novelty-suppressed feeding, Social interaction, and Tail suspension test. We also measured the levels of glucose, insulin and inflammatory cytokines such as IL-1β and TNF-α in the serum of the animals. The data were analyzed by Graphpad Primes. Results: The results indicated that type 2 diabetes significantly increased anhedonia- and depression-like behaviours in mice. Moreover, swimming exercise reduced anhedonia- and depression-like behaviour in type 2 diabetic mice. Swimming exercise also decreased glucose and inflammatory cytokines in the serum of mice with type 2 diabetes. Conclusion: Collectively, this study demonstrates that swimming exercise decreased depression-like behaviour by reducing inflammation in type 2 diabetic mice.Further clinical studies are needed to validate these findings in patients with type 2 diabetes.https://shenakht.muk.ac.ir/article-1-1948-en.htmltnf-αil-1βtype 2 diabetesexercise |
| spellingShingle | Mohadeseh Gilak dalasm Maghsoud Peeri Mohammad Ali Azarbaijani The effect of swimming training on inflammatory cytokines in serum of mice infected depression-type 2 diabetes روانشناسی و روانپزشکی شناخت tnf-α il-1β type 2 diabetes exercise |
| title | The effect of swimming training on inflammatory cytokines in serum of mice infected depression-type 2 diabetes |
| title_full | The effect of swimming training on inflammatory cytokines in serum of mice infected depression-type 2 diabetes |
| title_fullStr | The effect of swimming training on inflammatory cytokines in serum of mice infected depression-type 2 diabetes |
| title_full_unstemmed | The effect of swimming training on inflammatory cytokines in serum of mice infected depression-type 2 diabetes |
| title_short | The effect of swimming training on inflammatory cytokines in serum of mice infected depression-type 2 diabetes |
| title_sort | effect of swimming training on inflammatory cytokines in serum of mice infected depression type 2 diabetes |
| topic | tnf-α il-1β type 2 diabetes exercise |
| url | https://shenakht.muk.ac.ir/article-1-1948-en.html |
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