2D versus 3D tumor-on-chip models to study the impact of tumor organization on metabolic patterns in vitro

Abstract Despite the limitations of in vitro models to investigate cancer cell metabolism, their study can provide new insights essential for understanding tumorigenesis and effectively aiding in the development of novel therapies. The innovative tumor-on-chip models offer a more physiologically rel...

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Bibliographic Details
Main Authors: Paula Guerrero-López, Ana Martín-Pardillos, Javier Bonet-Aleta, Andrea Mosseri, Jose L. Hueso, Jesus Santamaria, Jose Manuel Garcia-Aznar
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-03504-8
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