Modelling rheumatoid arthritis: A hybrid modelling framework to describe pannus formation in a small joint
Rheumatoid arthritis (RA) is a chronic inflammatory disorder that causes pain, swelling and stiffness in the joints, and negatively impacts the life of affected patients. The disease does not have a cure yet, as there are still many aspects of this complex disorder that are not fully understood. Whi...
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Elsevier
2022-06-01
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| Series: | ImmunoInformatics |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667119022000064 |
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| author | Fiona R. Macfarlane Mark A.J. Chaplain Raluca Eftimie |
| author_facet | Fiona R. Macfarlane Mark A.J. Chaplain Raluca Eftimie |
| author_sort | Fiona R. Macfarlane |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a chronic inflammatory disorder that causes pain, swelling and stiffness in the joints, and negatively impacts the life of affected patients. The disease does not have a cure yet, as there are still many aspects of this complex disorder that are not fully understood. While mathematical models can shed light on some of these aspects, to date there are few such models that can be used to better understand the disease. As a first step in the mechanistic understanding of RA, in this study we introduce a new hybrid mathematical modelling framework that describes pannus formation in a small proximal interphalangeal (PIP) joint. We perform numerical simulations with this new model, to investigate the impact of different levels of immune cells (macrophages and fibroblasts) on the degradation of bone and cartilage. Since many model parameters are unknown and cannot be estimated due to a lack of experiments, we also perform a sensitivity analysis of model outputs to various model parameters (single parameters or combinations of parameters). Finally, we discuss how our model could be applied to investigate current treatments for RA, for example, methotrexate, TNF-inhibitors or tocilizumab, which can impact different model parameters. |
| format | Article |
| id | doaj-art-af5531dc2cb347a7aa2c259ab1b78de0 |
| institution | OA Journals |
| issn | 2667-1190 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | ImmunoInformatics |
| spelling | doaj-art-af5531dc2cb347a7aa2c259ab1b78de02025-08-20T02:37:06ZengElsevierImmunoInformatics2667-11902022-06-01610001410.1016/j.immuno.2022.100014Modelling rheumatoid arthritis: A hybrid modelling framework to describe pannus formation in a small jointFiona R. Macfarlane0Mark A.J. Chaplain1Raluca Eftimie2Corresponding author.; School of Mathematics and Statistics, University of St Andrews, UKSchool of Mathematics and Statistics, University of St Andrews, UKDépartement de Mathématiques, University of Franche-Comté, Besançon, FranceRheumatoid arthritis (RA) is a chronic inflammatory disorder that causes pain, swelling and stiffness in the joints, and negatively impacts the life of affected patients. The disease does not have a cure yet, as there are still many aspects of this complex disorder that are not fully understood. While mathematical models can shed light on some of these aspects, to date there are few such models that can be used to better understand the disease. As a first step in the mechanistic understanding of RA, in this study we introduce a new hybrid mathematical modelling framework that describes pannus formation in a small proximal interphalangeal (PIP) joint. We perform numerical simulations with this new model, to investigate the impact of different levels of immune cells (macrophages and fibroblasts) on the degradation of bone and cartilage. Since many model parameters are unknown and cannot be estimated due to a lack of experiments, we also perform a sensitivity analysis of model outputs to various model parameters (single parameters or combinations of parameters). Finally, we discuss how our model could be applied to investigate current treatments for RA, for example, methotrexate, TNF-inhibitors or tocilizumab, which can impact different model parameters.http://www.sciencedirect.com/science/article/pii/S2667119022000064Rheumatoid arthritisHybrid modelStochasticityImmune response |
| spellingShingle | Fiona R. Macfarlane Mark A.J. Chaplain Raluca Eftimie Modelling rheumatoid arthritis: A hybrid modelling framework to describe pannus formation in a small joint ImmunoInformatics Rheumatoid arthritis Hybrid model Stochasticity Immune response |
| title | Modelling rheumatoid arthritis: A hybrid modelling framework to describe pannus formation in a small joint |
| title_full | Modelling rheumatoid arthritis: A hybrid modelling framework to describe pannus formation in a small joint |
| title_fullStr | Modelling rheumatoid arthritis: A hybrid modelling framework to describe pannus formation in a small joint |
| title_full_unstemmed | Modelling rheumatoid arthritis: A hybrid modelling framework to describe pannus formation in a small joint |
| title_short | Modelling rheumatoid arthritis: A hybrid modelling framework to describe pannus formation in a small joint |
| title_sort | modelling rheumatoid arthritis a hybrid modelling framework to describe pannus formation in a small joint |
| topic | Rheumatoid arthritis Hybrid model Stochasticity Immune response |
| url | http://www.sciencedirect.com/science/article/pii/S2667119022000064 |
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