Serum adiponectin level is positively associated with vascular reactivity index by digital thermal monitoring in patients with coronary artery disease
Objectives: Adiponectin has anti-inflammatory and antiatherogenic effects and is important in the pathogenesis of cardiovascular diseases. In this cross-sectional study, our objective was to study the potential correlation between serum adiponectin levels and endothelial function in participants wit...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Tzu Chi Medical Journal |
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| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2023;volume=35;issue=4;spage=348;epage=354;aulast=Hsiao |
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| _version_ | 1850043590951043072 |
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| author | Chien-Hao Hsiao Bang-Gee Hsu Chia-Wen Lu Ji-Hung Wang |
| author_facet | Chien-Hao Hsiao Bang-Gee Hsu Chia-Wen Lu Ji-Hung Wang |
| author_sort | Chien-Hao Hsiao |
| collection | DOAJ |
| description | Objectives: Adiponectin has anti-inflammatory and antiatherogenic effects and is important in the pathogenesis of cardiovascular diseases. In this cross-sectional study, our objective was to study the potential correlation between serum adiponectin levels and endothelial function in participants with coronary artery disease (CAD). Materials and Methods: We collected serum specimens from 125 fasting participants with CAD. The endothelial function was measured using the vascular reactivity index (VRI) determined by digital thermal monitoring, and VRI values of >2.0, 1.0–1.9, and <1.0 indicated good, intermediate, and poor vascular reactivity, respectively. A commercially available enzyme immunoassay kit was used to measure serum adiponectin levels. Results: The cohort included 55, 57, and 13 patients with good, intermediate, and poor vascular reactivity, respectively. Poor vascular reactivity was shown to be associated with older age, higher levels of serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), C-reactive protein, and lower levels of serum albumin and adiponectin. The linear regression analysis with multivariable forward stepwise approach revealed that age (β = −0.232), serum LDL-C (β = −0.264), and serum adiponectin (β = 0.574) were correlated with the VRI in CAD patients significantly. Conclusion: Fasting serum adiponectin levels were associated with good endothelial function determined using the VRI in patients with CAD. |
| format | Article |
| id | doaj-art-af52bcd638a249d885fad4047fbbae71 |
| institution | DOAJ |
| issn | 1016-3190 2223-8956 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu Chi Medical Journal |
| spelling | doaj-art-af52bcd638a249d885fad4047fbbae712025-08-20T02:55:12ZengWolters Kluwer Medknow PublicationsTzu Chi Medical Journal1016-31902223-89562023-01-0135434835410.4103/tcmj.tcmj_30_23Serum adiponectin level is positively associated with vascular reactivity index by digital thermal monitoring in patients with coronary artery diseaseChien-Hao HsiaoBang-Gee HsuChia-Wen LuJi-Hung WangObjectives: Adiponectin has anti-inflammatory and antiatherogenic effects and is important in the pathogenesis of cardiovascular diseases. In this cross-sectional study, our objective was to study the potential correlation between serum adiponectin levels and endothelial function in participants with coronary artery disease (CAD). Materials and Methods: We collected serum specimens from 125 fasting participants with CAD. The endothelial function was measured using the vascular reactivity index (VRI) determined by digital thermal monitoring, and VRI values of >2.0, 1.0–1.9, and <1.0 indicated good, intermediate, and poor vascular reactivity, respectively. A commercially available enzyme immunoassay kit was used to measure serum adiponectin levels. Results: The cohort included 55, 57, and 13 patients with good, intermediate, and poor vascular reactivity, respectively. Poor vascular reactivity was shown to be associated with older age, higher levels of serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), C-reactive protein, and lower levels of serum albumin and adiponectin. The linear regression analysis with multivariable forward stepwise approach revealed that age (β = −0.232), serum LDL-C (β = −0.264), and serum adiponectin (β = 0.574) were correlated with the VRI in CAD patients significantly. Conclusion: Fasting serum adiponectin levels were associated with good endothelial function determined using the VRI in patients with CAD.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2023;volume=35;issue=4;spage=348;epage=354;aulast=Hsiaoadiponectincoronary artery diseaseendothelial dysfunctionvascular reactivity index |
| spellingShingle | Chien-Hao Hsiao Bang-Gee Hsu Chia-Wen Lu Ji-Hung Wang Serum adiponectin level is positively associated with vascular reactivity index by digital thermal monitoring in patients with coronary artery disease Tzu Chi Medical Journal adiponectin coronary artery disease endothelial dysfunction vascular reactivity index |
| title | Serum adiponectin level is positively associated with vascular reactivity index by digital thermal monitoring in patients with coronary artery disease |
| title_full | Serum adiponectin level is positively associated with vascular reactivity index by digital thermal monitoring in patients with coronary artery disease |
| title_fullStr | Serum adiponectin level is positively associated with vascular reactivity index by digital thermal monitoring in patients with coronary artery disease |
| title_full_unstemmed | Serum adiponectin level is positively associated with vascular reactivity index by digital thermal monitoring in patients with coronary artery disease |
| title_short | Serum adiponectin level is positively associated with vascular reactivity index by digital thermal monitoring in patients with coronary artery disease |
| title_sort | serum adiponectin level is positively associated with vascular reactivity index by digital thermal monitoring in patients with coronary artery disease |
| topic | adiponectin coronary artery disease endothelial dysfunction vascular reactivity index |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2023;volume=35;issue=4;spage=348;epage=354;aulast=Hsiao |
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