α-Synuclein ubiquitination – functions in proteostasis and development of Lewy bodies

α-Synuclein ubiquitination – functions in proteostasis and development of Lewy bodies

Synucleinopathies are neurodegenerative disorders characterized by the accumulation of α-synuclein containing Lewy bodies. Ubiquitination, a key post-translational modification, has been recognized as a pivotal regulator of α-synuclein’s cellular dynamics, influencing its degradation, aggregation, a...

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Bibliographic Details
Main Authors: Hung-Hsiang Ho, Simon S. Wing
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
α-synuclein
Lewy body
ubiquitin
Parkinson’s disease
endosome
lysosome
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1498459/full
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