Internal Standards for Quantitative Analysis of Chemical Warfare Agents by the GC/MS Method: Nerve Agents
General conditions and requirements for an internal standard useful in the determination of chemical warfare agents (CWAs) by the method of gas chromatography coupled with mass detection (GC/MS) were defined. The determination is based on a GC/MS analysis of a mixture of a CWA with an internal stand...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/8857210 |
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| author | Tomas Capoun Jana Krykorkova |
| author_facet | Tomas Capoun Jana Krykorkova |
| author_sort | Tomas Capoun |
| collection | DOAJ |
| description | General conditions and requirements for an internal standard useful in the determination of chemical warfare agents (CWAs) by the method of gas chromatography coupled with mass detection (GC/MS) were defined. The determination is based on a GC/MS analysis of a mixture of a CWA with an internal standard, conversion of the TIC chromatogram to a chromatogram extracted at a particular m/z ratio, and calculation of the CWA concentration from the internal standard concentration, response factor, and chromatographic peak areas. Available internal standards were identified, and they were verified for seven organophosphorus nerve-paralysing agents. Corresponding response factors were determined as a ratio of gradients of the linear functions of the peak area and compound concentration. Linearity, repeatability, and accuracy of the measurements were evaluated. The determination can be performed on all GC/MS systems of the Fire Rescue Service of the Czech Republic (FRS), where no CWA standards are available. |
| format | Article |
| id | doaj-art-af4b71b0b194435cbb7b5a7f1200cc9f |
| institution | OA Journals |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-af4b71b0b194435cbb7b5a7f1200cc9f2025-08-20T02:19:07ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732020-01-01202010.1155/2020/88572108857210Internal Standards for Quantitative Analysis of Chemical Warfare Agents by the GC/MS Method: Nerve AgentsTomas Capoun0Jana Krykorkova1Ministry of Interior—Directorate General of the Fire Rescue Service CR, Population Protection Institute, Na Luzci 204, Lazne Bohdanec 533 41, Czech RepublicMinistry of Interior—Directorate General of the Fire Rescue Service CR, Population Protection Institute, Na Luzci 204, Lazne Bohdanec 533 41, Czech RepublicGeneral conditions and requirements for an internal standard useful in the determination of chemical warfare agents (CWAs) by the method of gas chromatography coupled with mass detection (GC/MS) were defined. The determination is based on a GC/MS analysis of a mixture of a CWA with an internal standard, conversion of the TIC chromatogram to a chromatogram extracted at a particular m/z ratio, and calculation of the CWA concentration from the internal standard concentration, response factor, and chromatographic peak areas. Available internal standards were identified, and they were verified for seven organophosphorus nerve-paralysing agents. Corresponding response factors were determined as a ratio of gradients of the linear functions of the peak area and compound concentration. Linearity, repeatability, and accuracy of the measurements were evaluated. The determination can be performed on all GC/MS systems of the Fire Rescue Service of the Czech Republic (FRS), where no CWA standards are available.http://dx.doi.org/10.1155/2020/8857210 |
| spellingShingle | Tomas Capoun Jana Krykorkova Internal Standards for Quantitative Analysis of Chemical Warfare Agents by the GC/MS Method: Nerve Agents Journal of Analytical Methods in Chemistry |
| title | Internal Standards for Quantitative Analysis of Chemical Warfare Agents by the GC/MS Method: Nerve Agents |
| title_full | Internal Standards for Quantitative Analysis of Chemical Warfare Agents by the GC/MS Method: Nerve Agents |
| title_fullStr | Internal Standards for Quantitative Analysis of Chemical Warfare Agents by the GC/MS Method: Nerve Agents |
| title_full_unstemmed | Internal Standards for Quantitative Analysis of Chemical Warfare Agents by the GC/MS Method: Nerve Agents |
| title_short | Internal Standards for Quantitative Analysis of Chemical Warfare Agents by the GC/MS Method: Nerve Agents |
| title_sort | internal standards for quantitative analysis of chemical warfare agents by the gc ms method nerve agents |
| url | http://dx.doi.org/10.1155/2020/8857210 |
| work_keys_str_mv | AT tomascapoun internalstandardsforquantitativeanalysisofchemicalwarfareagentsbythegcmsmethodnerveagents AT janakrykorkova internalstandardsforquantitativeanalysisofchemicalwarfareagentsbythegcmsmethodnerveagents |