Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain
Abstract Neuropathic pain is a multifaceted syndrome posing significant challenges to patient quality of life and healthcare systems. Conventional treatments primarily focus on general pain modulation, which fail to address specific underlying mechanisms, leading to limited efficacy and infinite sid...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202502920 |
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| author | Yue Wang Xiuru Ji Yu Sun Han Wang Ting Wang Tao Luo Yanyong Cheng Jia Yan Dalong Ni Hong Jiang |
| author_facet | Yue Wang Xiuru Ji Yu Sun Han Wang Ting Wang Tao Luo Yanyong Cheng Jia Yan Dalong Ni Hong Jiang |
| author_sort | Yue Wang |
| collection | DOAJ |
| description | Abstract Neuropathic pain is a multifaceted syndrome posing significant challenges to patient quality of life and healthcare systems. Conventional treatments primarily focus on general pain modulation, which fail to address specific underlying mechanisms, leading to limited efficacy and infinite side effects. Calcitonin gene‐related peptide (CGRP) has played a pivotal role in neuro‐immune repair, contributing to vasodilation, nociception, and immune modulation following tissue injury. Herein, a bupivacaine‐loaded cerium‐based metal–organic framework (CUB) is designed to integrate sustained release of analgesia with immunomodulatory and antioxidant capabilities. In vivo models of chronic constriction injury (CCI) have demonstrated that CUB significantly reduced neuroinflammation, promoted M2 microglial polarization, and enhanced myelin regeneration for the prolonged analgesia. Deep mechanism analysis revealed that the designed CUB can significantly elevate TSP‐1 expression to activate CGRP signal in modulating the neuro‐immune interaction, contributing to the repair process. Notably, the CUB outperformed standalone bupivacaine or cerium nanoparticles in terms of pain relief, motor function recovery, and neuroglial regulation. The findings highlight the potential of CUB as a multifactorial therapeutic for treating neuropathic pain, offering new perspectives on the integration of nanotechnology in chronic pain management through neuro‐immune pathways. |
| format | Article |
| id | doaj-art-af4b4053fc544468a87c8ec9edc1f9a5 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-af4b4053fc544468a87c8ec9edc1f9a52025-08-20T03:41:08ZengWileyAdvanced Science2198-38442025-08-011229n/an/a10.1002/advs.202502920Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic PainYue Wang0Xiuru Ji1Yu Sun2Han Wang3Ting Wang4Tao Luo5Yanyong Cheng6Jia Yan7Dalong Ni8Hong Jiang9Department of Anesthesiology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 P. R. ChinaDepartment of Anesthesiology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 P. R. ChinaDepartment of Anesthesiology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. ChinaDepartment of Anesthesiology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. ChinaDepartment of Anesthesiology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. ChinaDepartment of Anesthesiology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 P. R. ChinaDepartment of Anesthesiology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. ChinaAbstract Neuropathic pain is a multifaceted syndrome posing significant challenges to patient quality of life and healthcare systems. Conventional treatments primarily focus on general pain modulation, which fail to address specific underlying mechanisms, leading to limited efficacy and infinite side effects. Calcitonin gene‐related peptide (CGRP) has played a pivotal role in neuro‐immune repair, contributing to vasodilation, nociception, and immune modulation following tissue injury. Herein, a bupivacaine‐loaded cerium‐based metal–organic framework (CUB) is designed to integrate sustained release of analgesia with immunomodulatory and antioxidant capabilities. In vivo models of chronic constriction injury (CCI) have demonstrated that CUB significantly reduced neuroinflammation, promoted M2 microglial polarization, and enhanced myelin regeneration for the prolonged analgesia. Deep mechanism analysis revealed that the designed CUB can significantly elevate TSP‐1 expression to activate CGRP signal in modulating the neuro‐immune interaction, contributing to the repair process. Notably, the CUB outperformed standalone bupivacaine or cerium nanoparticles in terms of pain relief, motor function recovery, and neuroglial regulation. The findings highlight the potential of CUB as a multifactorial therapeutic for treating neuropathic pain, offering new perspectives on the integration of nanotechnology in chronic pain management through neuro‐immune pathways.https://doi.org/10.1002/advs.202502920metal–organic frameworknanomedicineneuro‐immune interactionneuropathic pain |
| spellingShingle | Yue Wang Xiuru Ji Yu Sun Han Wang Ting Wang Tao Luo Yanyong Cheng Jia Yan Dalong Ni Hong Jiang Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain Advanced Science metal–organic framework nanomedicine neuro‐immune interaction neuropathic pain |
| title | Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain |
| title_full | Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain |
| title_fullStr | Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain |
| title_full_unstemmed | Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain |
| title_short | Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain |
| title_sort | nano anesthetics regulate neuro immune interaction for treating neuropathic pain |
| topic | metal–organic framework nanomedicine neuro‐immune interaction neuropathic pain |
| url | https://doi.org/10.1002/advs.202502920 |
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