Myeloid targeting antibodies PY159 and PY314 for platinum-resistant ovarian cancer

Myeloid targeting antibodies PY159 and PY314 for platinum-resistant ovarian cancer

Background Novel treatment options are required in patients with platinum-resistant ovarian cancer (PROC). Myeloid-derived suppressor cells promote a hostile tumor microenvironment and are associated with worse clinical outcomes in PROC. We evaluated the safety and preliminary efficacy of PY159, an...

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Main Authors: Afshin Dowlati, Judy Wang, Siqing Fu, Amita Patnaik, Minal Barve, Shivaani Kummar, Abdul Rafeh Naqash, Patricia LoRusso, Michael Gordon, Debra L Richardson, Ira Winer, Christos Kyriakopoulos, Joleen Hubbard, Marc Chamberlain, Oladapo O Yeku, Winston W Tan, Sarah K Lynam
Format: Article
Language:English
Published: BMJ Publishing Group 2025-03-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/3/e010959.full
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