Raffinose-metabolizing bacteria impair radiation-associated hematopoietic recovery via the bile acid/FXR/NF-κB signaling pathway

Raffinose-metabolizing bacteria impair radiation-associated hematopoietic recovery via the bile acid/FXR/NF-κB signaling pathway

Radiation-associated hematopoietic recovery (RAHR) is critical for mitigating lethal complications of acute radiation syndrome (ARS), yet therapeutic strategies remain limited. Through integrated multi-omics analysis of a total body irradiation (TBI) mouse model, we identify Bacteroides acidifaciens...

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Bibliographic Details
Main Authors: Yang Jiao, Jiawei Ren, Shichang Xie, Nan Yuan, Jiaqi Shen, Huafang Yin, Jian Wang, Hongjuan Guo, Jianping Cao, Xin Wang, Depei Wu, Zhemin Zhou, Xiaofei Qi
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Radiation-induced hematopoietic injury
gut microbiome
Bacteroides acidifaciens
raffinose-metabolizing bacteria
Intestinal-Hematopoietic Axis
UDCA
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2488105
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