A Cinderella story: how the vacuolar proteases Pep4 and Prb1 do more than cleaning up the cell’s mass degradation processes
Recently, several research groups have assigned non-vacuolar functions to the well-known Saccharomyces cerevisiae vacuolar proteases Pep4 and Prb1, which are also known as proteinases A and B. These non-vacuolar activities seem to be autophagy-independent and stress-induced and suggest an unexplored...
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| Language: | English |
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Shared Science Publishers OG
2018-09-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/a-cinderella-story-how-the-vacuolar-proteases-pep4-and-prb1-do-more-than-cleaning-up-the-cells-mass-degradation-processes/ |
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| author | Winnie Kerstens Patrick Van Dijck |
| author_facet | Winnie Kerstens Patrick Van Dijck |
| author_sort | Winnie Kerstens |
| collection | DOAJ |
| description | Recently, several research groups have assigned non-vacuolar functions to the well-known Saccharomyces cerevisiae vacuolar proteases Pep4 and Prb1, which are also known as proteinases A and B. These non-vacuolar activities seem to be autophagy-independent and stress-induced and suggest an unexplored but possibly prominent role for the proteases outside the vacuole. The functions range from the involvement in programmed cell death, to protection from hazardous protein forms and regulation of gene expression. We propose that a deeper understanding of these molecular processes will provide new insights that will be important for both fungal biology as well as studies in mammalian cells, as they might open up perspectives in the search for novel drug targets. To illustrate this, we summarize the recent literature on non-vacuolar Pep4 and Prb1 functions in S. cerevisiae and review the current data on the protein homologs in pathogenic fungi. |
| format | Article |
| id | doaj-art-af34ae2ee7ff403bbb6496f2589a9a04 |
| institution | DOAJ |
| issn | 2311-2638 |
| language | English |
| publishDate | 2018-09-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-af34ae2ee7ff403bbb6496f2589a9a042025-08-20T02:52:37ZengShared Science Publishers OGMicrobial Cell2311-26382018-09-0151043844310.15698/mic2018.10.650A Cinderella story: how the vacuolar proteases Pep4 and Prb1 do more than cleaning up the cell’s mass degradation processesWinnie Kerstens0Patrick Van Dijck1VIB-KU Leuven Center for Microbiology, Kasteelpark Arenberg 31, B-3001 Leuven, Belgium.VIB-KU Leuven Center for Microbiology, Kasteelpark Arenberg 31, B-3001 Leuven, Belgium.Recently, several research groups have assigned non-vacuolar functions to the well-known Saccharomyces cerevisiae vacuolar proteases Pep4 and Prb1, which are also known as proteinases A and B. These non-vacuolar activities seem to be autophagy-independent and stress-induced and suggest an unexplored but possibly prominent role for the proteases outside the vacuole. The functions range from the involvement in programmed cell death, to protection from hazardous protein forms and regulation of gene expression. We propose that a deeper understanding of these molecular processes will provide new insights that will be important for both fungal biology as well as studies in mammalian cells, as they might open up perspectives in the search for novel drug targets. To illustrate this, we summarize the recent literature on non-vacuolar Pep4 and Prb1 functions in S. cerevisiae and review the current data on the protein homologs in pathogenic fungi.http://microbialcell.com/researcharticles/a-cinderella-story-how-the-vacuolar-proteases-pep4-and-prb1-do-more-than-cleaning-up-the-cells-mass-degradation-processes/Pep4Prb1cathepsin Dproteaseprogrammed cell deathSAGAprionSaccharomyces cerevisiae |
| spellingShingle | Winnie Kerstens Patrick Van Dijck A Cinderella story: how the vacuolar proteases Pep4 and Prb1 do more than cleaning up the cell’s mass degradation processes Microbial Cell Pep4 Prb1 cathepsin D protease programmed cell death SAGA prion Saccharomyces cerevisiae |
| title | A Cinderella story: how the vacuolar proteases Pep4 and Prb1 do more than cleaning up the cell’s mass degradation processes |
| title_full | A Cinderella story: how the vacuolar proteases Pep4 and Prb1 do more than cleaning up the cell’s mass degradation processes |
| title_fullStr | A Cinderella story: how the vacuolar proteases Pep4 and Prb1 do more than cleaning up the cell’s mass degradation processes |
| title_full_unstemmed | A Cinderella story: how the vacuolar proteases Pep4 and Prb1 do more than cleaning up the cell’s mass degradation processes |
| title_short | A Cinderella story: how the vacuolar proteases Pep4 and Prb1 do more than cleaning up the cell’s mass degradation processes |
| title_sort | cinderella story how the vacuolar proteases pep4 and prb1 do more than cleaning up the cell s mass degradation processes |
| topic | Pep4 Prb1 cathepsin D protease programmed cell death SAGA prion Saccharomyces cerevisiae |
| url | http://microbialcell.com/researcharticles/a-cinderella-story-how-the-vacuolar-proteases-pep4-and-prb1-do-more-than-cleaning-up-the-cells-mass-degradation-processes/ |
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