Evolution of a major drug metabolizing enzyme defect in the domestic cat and other felidae: phylogenetic timing and the role of hypercarnivory.

Evolution of a major drug metabolizing enzyme defect in the domestic cat and other felidae: phylogenetic timing and the role of hypercarnivory.

The domestic cat (Felis catus) shows remarkable sensitivity to the adverse effects of phenolic drugs, including acetaminophen and aspirin, as well as structurally-related toxicants found in the diet and environment. This idiosyncrasy results from pseudogenization of the gene encoding UDP-glucuronosy...

Full description

Saved in:
Bibliographic Details
Main Authors: Binu Shrestha, J Michael Reed, Philip T Starks, Gretchen E Kaufman, Jared V Goldstone, Melody E Roelke, Stephen J O'Brien, Klaus-Peter Koepfli, Laurence G Frank, Michael H Court
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0018046&type=printable
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items