The binuclear cyclopalladated complex CP2 is targeting ubiquinol-cytochrome c reductase (complex III) of Leishmania amazonensis

The binuclear cyclopalladated complex CP2 is targeting ubiquinol-cytochrome c reductase (complex III) of Leishmania amazonensis

Leishmaniasis is a neglected disease that remains with a limited number of drugs available for chemotherapy and has an increased drug resistance that affects treatment outcomes. Metal-based drugs such as cyclopalladated complex [Pd(dmba)(μ-N3)]2 (CP2), a Leishmania topoisomerase IB inhibitor involve...

Full description

Saved in:

Bibliographic Details
Main Authors:	Angela Maria Arenas Velásquez, Irwin Alexander Patino Linares, Lawrence D. Gaspers, Paula J. Bartlett, Jecika M. Velasques, Adelino V.G. Netto, Andrew P. Thomas, Marcia A.S. Graminha
Format:	Article
Language:	English
Published:	Elsevier 2025-04-01
Series:	International Journal for Parasitology: Drugs and Drug Resistance
Subjects:	Leishmania amazonensis Cyclopalladated complex Ubiquinol-cytochrome c reductase Anti-leishmanial drug Mitochondrial oxygen consumption Mitochondrial calcium uniporter
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211320724000551
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Effects of 8-Week Creatine Supplementation With and Without Ubiquinol on Sperm Creatine Metabolism Biomarkers
by: David Nedeljkovic, et al.
Published: (2025-09-01)

Embryos extract from germinated yellow soybean (Glycine max [L.] Merrill) inhibits promastigotes form of Leishmania amazonensis
by: P. M. Pedrote, et al.
Published: (2025-06-01)

Features of the influence of the antioxidant ethylmethylhydroxypyridine malate and the drug ubidecarenone on plasma concentrations of ubiquinone, ubiquinol and the redox state of coenzyme Q10
by: V. I. Zozina, et al.
Published: (2024-01-01)

How vanadium and manganese compounds impact cardiac mitochondrial function
by: Connor C. Dolan, et al.
Published: (2025-06-01)

Flavonoids in the treatment of Leishmania amazonensis: a review of efficacy and mechanisms
by: Vinicius Lopes Lessa, et al.
Published: (2025-08-01)

Effect of Leishmania proteins in mice: Investigation of Leishmania amazonensis virulence molecules for therapy and prophylaxis of leishmaniasis
by: Cintia Figueiredo de Araújo, et al.
Published: (2025-03-01)

Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly
by: Haixin Zhao, et al.
Published: (2025-05-01)

Genetic Predisposition and Mitochondrial Dysfunction in Sudden Cardiac Death: Role of MCU Complex Genetic Variations
by: Haoliang Meng, et al.
Published: (2025-05-01)

Synthesis and Structure–Activity Relationship of Thiourea Derivatives Against <i>Leishmania amazonensis</i>
by: Gil Mendes Viana, et al.
Published: (2024-11-01)

Structural and functional characterization of the cardiac mitochondria-associated reticular membranes in the ob/ob mouse model
by: Hala Guedouari, et al.
Published: (2025-06-01)

MCU expression in hippocampal CA2 neurons modulates dendritic mitochondrial morphology and synaptic plasticity
by: Katy E. Pannoni, et al.
Published: (2025-02-01)

Genome-Wide Identification and Expression Profiling Analysis of the Mitochondrial Calcium Uniporter Gene Family Under Abiotic Stresses in <i>Medicago sativa</i>
by: Wanhong Li, et al.
Published: (2024-11-01)

IN SILICO AND IN VITRO ACTIVITY OF FRIEDELIN N-DERIVATIVES AGAINST PROMASTIGOTE FORMS OF Leishmania amazonensis
by: Mauro Lúcio Gonçalves de Oliveira, et al.
Published: (2025-08-01)

Cutaneous leishmaniasis presenting as dactylitis and paronychia in an immunocompetent individual: Case report of a rare condition from Tuscany region, Italy
by: Roberta Maria Antonello, et al.
Published: (2025-05-01)

Systematic suppression of Leishmania (Leishmania) amazonensis-mediated delayed-type hypersensitivity response in American cutaneous leishmaniasis
by: Marliane B. Campos, et al.
Published: (2025-08-01)

THE MODERN METHODS OF ANALYSIS OF OXIDIZED AND REDUCED FORMS OF COENZYME Q₁₀ IN BIOMATERIAL (REVIEW)
by: V. I. Zozina, et al.
Published: (2019-01-01)

Inter-Organellar Ca<sup>2+</sup> Homeostasis in Plant and Animal Systems
by: Philip Steiner, et al.
Published: (2025-08-01)

In vitro and in vivo evaluation of the leishmanicidal and cytotoxic activities of chitosan and chitosan–amphotericin B
by: Parisa Mousavi, et al.
Published: (2025-04-01)

Effects of coenzyme Q10 administration on blood pressure and heart rate in adults: A systematic review and meta-analysis of randomized controlled trials
by: Mehdi Karimi, et al.
Published: (2025-09-01)

The Role of Autophagy in Excitotoxicity, Synaptic Mitochondrial Stress and Neurodegeneration
by: Charleen T. Chu
Published: (2025-12-01)

Anti-leishmanial effect of the hydroalcoholic extract of the leaves, roots and seeds of Arctium lappa
by: Elham Maleki, et al.
Published: (2025-03-01)

Meliponini Geopropolis Extracts Induce ROS Production and Death in <i>Leishmania amazonensis</i> Promastigotes and Axenic Amastigotes In Vitro
by: Kamila M. Sette, et al.
Published: (2025-02-01)

Clinical Outcomes of Uniportal Versus Multiportal Endoscopic Thoracic Sympathectomy in Patients With Severe Palmar and Axillary Hyperhidrosis
by: Oktay Aslaner
Published: (2022-08-01)

2-aminoethoxydiphenylborane intervenes intracellular calcium signaling and attenuates myocardial ischemia-reperfusion injury in mice through ITPR1/MCU pathway
by: Hailong Bao, et al.
Published: (2025-08-01)

Metabolic effects of bezafibrate in mitochondrial disease
by: Hannah Steele, et al.
Published: (2020-02-01)

Mitochondrial disease in adults: what's old and what's new?
by: Patrick F Chinnery
Published: (2015-11-01)

HADHA Regulates Respiratory Complex Assembly and Couples FAO and OXPHOS
by: Chaoying Qin, et al.
Published: (2024-12-01)

Mitochondrial DNA Haplogroups Frequency Analysis among North Indian Population: A Resource for Establishing Maternal Relationships in Solid Organ Transplantation
by: Vikash Chandra Mishra, et al.
Published: (2025-01-01)

Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities
by: Yun Liao, et al.
Published: (2025-04-01)

Mitochondrial quality control and transfer communication in neurological disorders and neuroinflammation
by: Yinrui Ma, et al.
Published: (2025-04-01)

Single-cell mitochondrial DNA sequencing: Methodologies and applications
by: Guoqiang Zhou, et al.
Published: (2024-01-01)

The Bemisia tabaci Species Complex: Questions to Guide Future Research
by: Paul J De Barro
Published: (2012-02-01)

Mitochondrial quality control: a pathophysiological mechanism and potential therapeutic target for chronic obstructive pulmonary disease
by: Mengjiao Xu, et al.
Published: (2025-01-01)

Renal phenotyping in a hypomorphic murine model of propionic aciduria reveals common pathomechanisms in organic acidurias
by: Anke Schumann, et al.
Published: (2024-12-01)

Biosynthesis of anti-leishmanial natural products in callus cultures of Artemisia scoparia
by: Reema Yousaf, et al.
Published: (2019-12-01)

DNA methylation of long noncoding RNA cytochrome B in diabetic retinopathy
by: Renu A. Kowluru, et al.
Published: (2025-04-01)

Healing and leishmanicidal activity of Zanthoxylum rhoifolium Lam.
by: Juliana Correa-Barbosa, et al.
Published: (2025-04-01)

Mitochondria of transformed cell as a target of antitumor influence
by: E. M. Frantsiyants, et al.
Published: (2020-06-01)

Significance of Mitochondrial Dynamics in Reproductive Physiology: Current and Emerging Horizons in Mitochondrial Therapy for Assisted Reproductive Technologies
by: Sanath Udayanga Kankanam Gamage, et al.
Published: (2025-01-01)

The role of mitochondrial biogenesis, mitochondrial dynamics and mitophagy in gastrointestinal tumors
by: Yihong Liu, et al.
Published: (2025-02-01)