SORBS3-β suppresses lymph node metastasis in cervical cancer by promoting the ubiquitination of β-catenin

SORBS3-β suppresses lymph node metastasis in cervical cancer by promoting the ubiquitination of β-catenin

Abstract Background Cervical cancer (CC) is a prevalent gynecological malignancy, with lymph node metastasis (LNM) serving as a critical factor influencing patient prognosis. SORBS3, an adaptor protein with two known isoforms (α and β), has been implicated in tumor suppression, but the specific role...

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Bibliographic Details
Main Authors: Huating Sun, Yinghui Zhang, Fang Wang, Zizhao Wang, Yuhong Zhang, Youguo Chen, Li Wang, Jinhua Zhou
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
Cervical cancer
SORBS3-β
Wnt/β-catenin
Lymph node metastasis
Online Access:https://doi.org/10.1186/s12967-025-06409-2
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