Peripheral Ulcerative Keratitis Associated with HCV-Related Cryoglobulinemia
Purpose. To describe a case of peripheral ulcerative keratitis associated with type II cryoglobulinemia in the context of Hepatitis C infection. Methods. Case report and literature review. Results. A 36-year-old male patient presented to our emergency department with unilateral moderate pain in his...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Ophthalmological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/9461937 |
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| author | Pedro Coelho Carlos Menezes Rita Gonçalves Pedro Rodrigues Elena Seara |
| author_facet | Pedro Coelho Carlos Menezes Rita Gonçalves Pedro Rodrigues Elena Seara |
| author_sort | Pedro Coelho |
| collection | DOAJ |
| description | Purpose. To describe a case of peripheral ulcerative keratitis associated with type II cryoglobulinemia in the context of Hepatitis C infection. Methods. Case report and literature review. Results. A 36-year-old male patient presented to our emergency department with unilateral moderate pain in his right eye, associated with redness and photophobia. Medical background elicited a history of Hepatitis C and IV illicit drug abuse. Ocular examination revealed a BCVA of 20/30 of the affected eye and slight discomfort with eye movement. Biomicroscopy revealed a ring shaped peripheral corneal ulcer, with a dense white stromal infiltrate sparing the limbus, plus an adjacent area of mild anterior diffuse nonnecrotizing scleritis. No intraocular inflammation was present. Posterior segment was normal. The patient was placed under oral prednisolone (1 mg/Kg/day) with gradual tapering. A dramatic clinical response occurred, with complete resolution of the clinical condition. Systemic analytic workup aiming at autoimmune and infectious diseases was negative, except for high HCV-viral load and the presence of type 2 cryoglobulins. Conclusion. Albeit rare, cryoglobulinemia, even in the absence of systemic vasculitis, should be considered in the differential diagnosis of PUK, when systemic workout for autoimmune diseases is negative. |
| format | Article |
| id | doaj-art-af19fe0e12374467b927d4402ef97380 |
| institution | Kabale University |
| issn | 2090-6722 2090-6730 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Ophthalmological Medicine |
| spelling | doaj-art-af19fe0e12374467b927d4402ef973802025-08-20T03:39:06ZengWileyCase Reports in Ophthalmological Medicine2090-67222090-67302017-01-01201710.1155/2017/94619379461937Peripheral Ulcerative Keratitis Associated with HCV-Related CryoglobulinemiaPedro Coelho0Carlos Menezes1Rita Gonçalves2Pedro Rodrigues3Elena Seara4Department of Ophthalmology, Hospital Pedro Hispano, Matosinhos, PortugalDepartment of Ophthalmology, Hospital de Santa Luzia, Viana do Castelo, PortugalDepartment of Ophthalmology, Hospital Pedro Hispano, Matosinhos, PortugalDepartment of Ophthalmology, Hospital Pedro Hispano, Matosinhos, PortugalDepartment of Ophthalmology, Hospital Pedro Hispano, Matosinhos, PortugalPurpose. To describe a case of peripheral ulcerative keratitis associated with type II cryoglobulinemia in the context of Hepatitis C infection. Methods. Case report and literature review. Results. A 36-year-old male patient presented to our emergency department with unilateral moderate pain in his right eye, associated with redness and photophobia. Medical background elicited a history of Hepatitis C and IV illicit drug abuse. Ocular examination revealed a BCVA of 20/30 of the affected eye and slight discomfort with eye movement. Biomicroscopy revealed a ring shaped peripheral corneal ulcer, with a dense white stromal infiltrate sparing the limbus, plus an adjacent area of mild anterior diffuse nonnecrotizing scleritis. No intraocular inflammation was present. Posterior segment was normal. The patient was placed under oral prednisolone (1 mg/Kg/day) with gradual tapering. A dramatic clinical response occurred, with complete resolution of the clinical condition. Systemic analytic workup aiming at autoimmune and infectious diseases was negative, except for high HCV-viral load and the presence of type 2 cryoglobulins. Conclusion. Albeit rare, cryoglobulinemia, even in the absence of systemic vasculitis, should be considered in the differential diagnosis of PUK, when systemic workout for autoimmune diseases is negative.http://dx.doi.org/10.1155/2017/9461937 |
| spellingShingle | Pedro Coelho Carlos Menezes Rita Gonçalves Pedro Rodrigues Elena Seara Peripheral Ulcerative Keratitis Associated with HCV-Related Cryoglobulinemia Case Reports in Ophthalmological Medicine |
| title | Peripheral Ulcerative Keratitis Associated with HCV-Related Cryoglobulinemia |
| title_full | Peripheral Ulcerative Keratitis Associated with HCV-Related Cryoglobulinemia |
| title_fullStr | Peripheral Ulcerative Keratitis Associated with HCV-Related Cryoglobulinemia |
| title_full_unstemmed | Peripheral Ulcerative Keratitis Associated with HCV-Related Cryoglobulinemia |
| title_short | Peripheral Ulcerative Keratitis Associated with HCV-Related Cryoglobulinemia |
| title_sort | peripheral ulcerative keratitis associated with hcv related cryoglobulinemia |
| url | http://dx.doi.org/10.1155/2017/9461937 |
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