New drugs for acute kidney injury
Acute kidney injury (AKI) presents a significant challenge in the management of critically ill patients, as it is associated with increased mortality, prolonged hospital stays, and increased healthcare costs. In certain conditions, such as during sepsis or after cardiac surgery, AKI is one of the mo...
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Elsevier
2025-01-01
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| Series: | Journal of Intensive Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667100X24000914 |
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| author | Geoffroy Hariri Matthieu Legrand |
| author_facet | Geoffroy Hariri Matthieu Legrand |
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| collection | DOAJ |
| description | Acute kidney injury (AKI) presents a significant challenge in the management of critically ill patients, as it is associated with increased mortality, prolonged hospital stays, and increased healthcare costs. In certain conditions, such as during sepsis or after cardiac surgery, AKI is one of the most frequent complications, affecting 30%–50% of patients. Over time, even after the resolution of AKI, it can evolve into chronic kidney disease, a leading global cause of mortality, and cardiovascular complications. Despite significant improvement in the care of critically ill patients over the past two decades, the incidence of AKI remains stable, and novel approaches aiming at reducing its occurrence or improving AKI outcomes are still mostly lacking. However, recent insights into the pathophysiology of AKI within critical care settings have shed light on new pathways for both prevention and treatment, providing various new therapeutic targets aimed to mitigating kidney injury. These advancements highlight the intricate and multifaceted nature of the mechanisms underlying AKI, which could explain the challenge of identifying an effective treatment. Among these targets, modulation of the inflammatory responses and the cellular metabolism, hemodynamic regulation and enhancement of cellular repair mechanisms, have emerged as promising options. These multifaceted approaches offer renewed hope for limiting the incidence and severity of AKI in critically ill patients. Several ongoing clinical trials are evaluating the efficacy of these different strategies and we are facing an exiting time with multiple therapeutic interventions being tested to prevent or treat AKI. In this review, we aim to provide a summary of the new drugs evaluated for preventing or treating AKI in critical care and surgical settings. |
| format | Article |
| id | doaj-art-af1456162a634c6ba492979d1b7c63ff |
| institution | Kabale University |
| issn | 2667-100X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Intensive Medicine |
| spelling | doaj-art-af1456162a634c6ba492979d1b7c63ff2025-01-05T04:28:47ZengElsevierJournal of Intensive Medicine2667-100X2025-01-0151311New drugs for acute kidney injuryGeoffroy Hariri0Matthieu Legrand1Department of Anesthesia and Perioperative Care, Division of Critical Care Medicine, UCSF, San Francisco, CA, USA; Sorbonne Université, GRC 29, Assistance Publique-Hôpitaux de Paris (AP-HP), DMU DREAM, Département d'anesthésie et réanimation, Institut de Cardiologie, Hôpital La Pitié-Salpêtrière, Paris, FranceDepartment of Anesthesia and Perioperative Care, Division of Critical Care Medicine, UCSF, San Francisco, CA, USA; Investigation Network Initiative Cardiovascular and Renal Clinical Trialist Network, Nancy, France; Corresponding author: Matthieu Legrand, Department of Anesthesia and Perioperative Care, Division of Critical Care Medicine, UCSF, 521 Parnassus Avenue, San Francisco, CA 94143, USA.Acute kidney injury (AKI) presents a significant challenge in the management of critically ill patients, as it is associated with increased mortality, prolonged hospital stays, and increased healthcare costs. In certain conditions, such as during sepsis or after cardiac surgery, AKI is one of the most frequent complications, affecting 30%–50% of patients. Over time, even after the resolution of AKI, it can evolve into chronic kidney disease, a leading global cause of mortality, and cardiovascular complications. Despite significant improvement in the care of critically ill patients over the past two decades, the incidence of AKI remains stable, and novel approaches aiming at reducing its occurrence or improving AKI outcomes are still mostly lacking. However, recent insights into the pathophysiology of AKI within critical care settings have shed light on new pathways for both prevention and treatment, providing various new therapeutic targets aimed to mitigating kidney injury. These advancements highlight the intricate and multifaceted nature of the mechanisms underlying AKI, which could explain the challenge of identifying an effective treatment. Among these targets, modulation of the inflammatory responses and the cellular metabolism, hemodynamic regulation and enhancement of cellular repair mechanisms, have emerged as promising options. These multifaceted approaches offer renewed hope for limiting the incidence and severity of AKI in critically ill patients. Several ongoing clinical trials are evaluating the efficacy of these different strategies and we are facing an exiting time with multiple therapeutic interventions being tested to prevent or treat AKI. In this review, we aim to provide a summary of the new drugs evaluated for preventing or treating AKI in critical care and surgical settings.http://www.sciencedirect.com/science/article/pii/S2667100X24000914Acute kidney injuryDrugsCritical careInnovative therapiesTargeted care |
| spellingShingle | Geoffroy Hariri Matthieu Legrand New drugs for acute kidney injury Journal of Intensive Medicine Acute kidney injury Drugs Critical care Innovative therapies Targeted care |
| title | New drugs for acute kidney injury |
| title_full | New drugs for acute kidney injury |
| title_fullStr | New drugs for acute kidney injury |
| title_full_unstemmed | New drugs for acute kidney injury |
| title_short | New drugs for acute kidney injury |
| title_sort | new drugs for acute kidney injury |
| topic | Acute kidney injury Drugs Critical care Innovative therapies Targeted care |
| url | http://www.sciencedirect.com/science/article/pii/S2667100X24000914 |
| work_keys_str_mv | AT geoffroyhariri newdrugsforacutekidneyinjury AT matthieulegrand newdrugsforacutekidneyinjury |