Reward monitoring in the frontopolar cortex of macaques
Abstract Reward processing involves several prefrontal cortex areas, enabling individuals to learn from behavioral outcomes and shape decisions. However, the role of the frontopolar cortex (FPC) in these processes remains unclear due to limited single-neuron research. In this study, we recorded neur...
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-99019-3 |
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| author | Lorenzo Ferrucci Francesco Ceccarelli Fabrizio Londei Giulia Arena Leyla Elyasizad Simon Nougaret Aldo Genovesio |
| author_facet | Lorenzo Ferrucci Francesco Ceccarelli Fabrizio Londei Giulia Arena Leyla Elyasizad Simon Nougaret Aldo Genovesio |
| author_sort | Lorenzo Ferrucci |
| collection | DOAJ |
| description | Abstract Reward processing involves several prefrontal cortex areas, enabling individuals to learn from behavioral outcomes and shape decisions. However, the role of the frontopolar cortex (FPC) in these processes remains unclear due to limited single-neuron research. In this study, we recorded neural activity from the FPC of two macaques performing a fast-learning task, the object-in-place reward task, which examined how reward size affects learning. Results showed that FPC feedback monitoring activity extends to the value of specific choices. Moreover, once the association between scenes and reward had been learned, FPC neural activity before choice reflected the future animal’s behavior to stay or to switch on their previous behavioral strategy, i.e., to choose the same target or the other one. These results suggest that FPC neurons integrated information for action monitoring and later reprocessed it to decide the best behavioral strategy to adopt, determining whether to maintain or change the action plan. |
| format | Article |
| id | doaj-art-af12e470118e4b108cee96904a89193f |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-af12e470118e4b108cee96904a89193f2025-08-20T03:10:12ZengNature PortfolioScientific Reports2045-23222025-05-0115111410.1038/s41598-025-99019-3Reward monitoring in the frontopolar cortex of macaquesLorenzo Ferrucci0Francesco Ceccarelli1Fabrizio Londei2Giulia Arena3Leyla Elyasizad4Simon Nougaret5Aldo Genovesio6Department of Physiology and Pharmacology, Sapienza University of RomeDepartment of Physiology and Pharmacology, Sapienza University of RomeDepartment of Physiology and Pharmacology, Sapienza University of RomeDepartment of Physiology and Pharmacology, Sapienza University of RomeDepartment of Physiology and Pharmacology, Sapienza University of RomeInstitut de Neurosciences de La Timone, UMR 7289, Centre National de La Recherche Scientifique and Aix-Marseille UniversiteDepartment of Physiology and Pharmacology, Sapienza University of RomeAbstract Reward processing involves several prefrontal cortex areas, enabling individuals to learn from behavioral outcomes and shape decisions. However, the role of the frontopolar cortex (FPC) in these processes remains unclear due to limited single-neuron research. In this study, we recorded neural activity from the FPC of two macaques performing a fast-learning task, the object-in-place reward task, which examined how reward size affects learning. Results showed that FPC feedback monitoring activity extends to the value of specific choices. Moreover, once the association between scenes and reward had been learned, FPC neural activity before choice reflected the future animal’s behavior to stay or to switch on their previous behavioral strategy, i.e., to choose the same target or the other one. These results suggest that FPC neurons integrated information for action monitoring and later reprocessed it to decide the best behavioral strategy to adopt, determining whether to maintain or change the action plan.https://doi.org/10.1038/s41598-025-99019-3Frontal poleArea 10MonkeyRewardExplore-exploitLearning |
| spellingShingle | Lorenzo Ferrucci Francesco Ceccarelli Fabrizio Londei Giulia Arena Leyla Elyasizad Simon Nougaret Aldo Genovesio Reward monitoring in the frontopolar cortex of macaques Scientific Reports Frontal pole Area 10 Monkey Reward Explore-exploit Learning |
| title | Reward monitoring in the frontopolar cortex of macaques |
| title_full | Reward monitoring in the frontopolar cortex of macaques |
| title_fullStr | Reward monitoring in the frontopolar cortex of macaques |
| title_full_unstemmed | Reward monitoring in the frontopolar cortex of macaques |
| title_short | Reward monitoring in the frontopolar cortex of macaques |
| title_sort | reward monitoring in the frontopolar cortex of macaques |
| topic | Frontal pole Area 10 Monkey Reward Explore-exploit Learning |
| url | https://doi.org/10.1038/s41598-025-99019-3 |
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