Aneurysmal Subarachnoid Hemorrhage Models: Do They Need a Fix?
The discovery of tissue plasminogen activator to treat acute stroke is a success story of research on preventing brain injury following transient cerebral ischemia (TGI). That this discovery depended upon development of embolic animal model reiterates that proper stroke modeling is the key to develo...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2013/615154 |
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| author | Fatima A. Sehba Ryszard M. Pluta |
| author_facet | Fatima A. Sehba Ryszard M. Pluta |
| author_sort | Fatima A. Sehba |
| collection | DOAJ |
| description | The discovery of tissue plasminogen activator to treat acute stroke is a success story of research on preventing brain injury following transient cerebral ischemia (TGI). That this discovery depended upon development of embolic animal model reiterates that proper stroke modeling is the key to develop new treatments. In contrast to TGI, despite extensive research, prevention or treatment of brain injury following aneurysmal subarachnoid hemorrhage (aSAH) has not been achieved. A lack of adequate aSAH disease model may have contributed to this failure. TGI is an important component of aSAH and shares mechanism of injury with it. We hypothesized that modifying aSAH model using experience acquired from TGI modeling may facilitate development of treatment for aSAH and its complications. This review focuses on similarities and dissimilarities between TGI and aSAH, discusses the existing TGI and aSAH animal models, and presents a modified aSAH model which effectively mimics the disease and has a potential of becoming a better resource for studying the brain injury mechanisms and developing a treatment. |
| format | Article |
| id | doaj-art-af0ebf3acf6f48848883c38441a2ada2 |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-af0ebf3acf6f48848883c38441a2ada22025-02-03T01:06:19ZengWileyStroke Research and Treatment2090-81052042-00562013-01-01201310.1155/2013/615154615154Aneurysmal Subarachnoid Hemorrhage Models: Do They Need a Fix?Fatima A. Sehba0Ryszard M. Pluta1Departments of Neurosurgery and Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USASurgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USAThe discovery of tissue plasminogen activator to treat acute stroke is a success story of research on preventing brain injury following transient cerebral ischemia (TGI). That this discovery depended upon development of embolic animal model reiterates that proper stroke modeling is the key to develop new treatments. In contrast to TGI, despite extensive research, prevention or treatment of brain injury following aneurysmal subarachnoid hemorrhage (aSAH) has not been achieved. A lack of adequate aSAH disease model may have contributed to this failure. TGI is an important component of aSAH and shares mechanism of injury with it. We hypothesized that modifying aSAH model using experience acquired from TGI modeling may facilitate development of treatment for aSAH and its complications. This review focuses on similarities and dissimilarities between TGI and aSAH, discusses the existing TGI and aSAH animal models, and presents a modified aSAH model which effectively mimics the disease and has a potential of becoming a better resource for studying the brain injury mechanisms and developing a treatment.http://dx.doi.org/10.1155/2013/615154 |
| spellingShingle | Fatima A. Sehba Ryszard M. Pluta Aneurysmal Subarachnoid Hemorrhage Models: Do They Need a Fix? Stroke Research and Treatment |
| title | Aneurysmal Subarachnoid Hemorrhage Models: Do They Need a Fix? |
| title_full | Aneurysmal Subarachnoid Hemorrhage Models: Do They Need a Fix? |
| title_fullStr | Aneurysmal Subarachnoid Hemorrhage Models: Do They Need a Fix? |
| title_full_unstemmed | Aneurysmal Subarachnoid Hemorrhage Models: Do They Need a Fix? |
| title_short | Aneurysmal Subarachnoid Hemorrhage Models: Do They Need a Fix? |
| title_sort | aneurysmal subarachnoid hemorrhage models do they need a fix |
| url | http://dx.doi.org/10.1155/2013/615154 |
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