α-methyltryptophan-mediated protection against diabetic nephropathy in db/db mice as studied with a metabolomics approach

α-methyltryptophan-mediated protection against diabetic nephropathy in db/db mice as studied with a metabolomics approach

IntroductionDiabetic nephropathy (DN), a major complication of diabetes, presents with poor clinical outcomes and affects patients throughout their lifetime. α-Methyltryptophan (α-MT) is a blocker of the amino acid transporter. SLC6A14 and also an inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1).Me...

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Main Authors: Aimin Cai, Dingchao Shen, Qiushuang Xiong, Jie Ding, Yang Ding, Xinlu Lin, Lijia Chen, Qing Yao, Guangyong Lin, Ruijie Chen, Vadivel Ganapathy, Longfa Kou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
α-methyltryptophan
diabetic nephropathy
mTOR
apoptosis
metabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1463673/full
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