Coevolution of Lentiviral Vif with Host A3F and A3G: Insights from Computational Modelling and Ancestral Sequence Reconstruction

Coevolution of Lentiviral Vif with Host A3F and A3G: Insights from Computational Modelling and Ancestral Sequence Reconstruction

The evolutionary arms race between host restriction factors and viral antagonists provides crucial insights into immune system evolution and viral adaptation. This study investigates the structural and evolutionary dynamics of the double-domain restriction factors A3F and A3G and their viral inhibit...

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Bibliographic Details
Main Authors: David Nicolas Giuseppe Huebert, Atefeh Ghorbani, Shaw Yick Brian Lam, Mani Larijani
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Viruses
Subjects:
Apobec3
Vif
lentiviruses
host–viral coevolution
viral antagonists
deamination
Online Access:https://www.mdpi.com/1999-4915/17/3/393
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