Materials and devices for high‐density, high‐throughput micro‐electrocorticography arrays
The pursuit of precisely recording and localizing neural activities in brain cortical regions drives the development of advanced electrocorticography (ECoG) devices. Remarkable progress has led to the emergence of micro-ECoG (µECoG) devices with sub-millimeter resolutions. This review presents the c...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2025-01-01
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| Series: | Fundamental Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325824000402 |
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| author | Yang Xie Yanxiu Peng Jinhong Guo Muyang Liu Bozhen Zhang Lan Yin He Ding Xing Sheng |
| author_facet | Yang Xie Yanxiu Peng Jinhong Guo Muyang Liu Bozhen Zhang Lan Yin He Ding Xing Sheng |
| author_sort | Yang Xie |
| collection | DOAJ |
| description | The pursuit of precisely recording and localizing neural activities in brain cortical regions drives the development of advanced electrocorticography (ECoG) devices. Remarkable progress has led to the emergence of micro-ECoG (µECoG) devices with sub-millimeter resolutions. This review presents the current research status, development directions, potential innovations and applications of high-density, high-throughput µECoG devices. First, we summarize the challenges associated with accurately recording single or multiple neurons using existing µECoG devices, including passive multielectrode and active transistor arrays. Second, we focus on cutting-edge advancements in passive µECoG devices by discussing the design principles and fabrication strategies to optimize three key parameters: impedance, mechanical flexibility, and biocompatibility. Furthermore, recent findings highlight the need for further research and development in active transistor arrays, including silicon, metal oxide, and solution-gated transistors. These active transistor arrays have the potential to unlock the capabilities of high-density, high-throughput µECoG devices and overcome the limitations of passive multielectrode arrays. The review explores the potential innovations and applications of µECoG devices, showcasing their effectiveness for both brain science research and clinical applications. |
| format | Article |
| id | doaj-art-af078567b83d4c34aa76f4fbdf4b3abf |
| institution | Kabale University |
| issn | 2667-3258 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj-art-af078567b83d4c34aa76f4fbdf4b3abf2025-01-29T05:02:35ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582025-01-01511728Materials and devices for high‐density, high‐throughput micro‐electrocorticography arraysYang Xie0Yanxiu Peng1Jinhong Guo2Muyang Liu3Bozhen Zhang4Lan Yin5He Ding6Xing Sheng7Department of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Institute for Precision Medicine, Laboratory of Flexible Electronics Technology, IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing 100084, ChinaBeijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optics and Photonics, Beijing Institute of Technology, Beijing 100081, ChinaDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Institute for Precision Medicine, Laboratory of Flexible Electronics Technology, IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing 100084, ChinaDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Institute for Precision Medicine, Laboratory of Flexible Electronics Technology, IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing 100084, ChinaSchool of Materials Science and Engineering, The Key Laboratory of Advanced Materials of Ministry of Education, State Key Laboratory of New Ceramics and Fine Processing, Laboratory of Flexible Electronics Technology, Tsinghua University, Beijing 100084, ChinaSchool of Materials Science and Engineering, The Key Laboratory of Advanced Materials of Ministry of Education, State Key Laboratory of New Ceramics and Fine Processing, Laboratory of Flexible Electronics Technology, Tsinghua University, Beijing 100084, ChinaBeijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optics and Photonics, Beijing Institute of Technology, Beijing 100081, China; Corresponding authors.Department of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Institute for Precision Medicine, Laboratory of Flexible Electronics Technology, IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing 100084, China; Corresponding authors.The pursuit of precisely recording and localizing neural activities in brain cortical regions drives the development of advanced electrocorticography (ECoG) devices. Remarkable progress has led to the emergence of micro-ECoG (µECoG) devices with sub-millimeter resolutions. This review presents the current research status, development directions, potential innovations and applications of high-density, high-throughput µECoG devices. First, we summarize the challenges associated with accurately recording single or multiple neurons using existing µECoG devices, including passive multielectrode and active transistor arrays. Second, we focus on cutting-edge advancements in passive µECoG devices by discussing the design principles and fabrication strategies to optimize three key parameters: impedance, mechanical flexibility, and biocompatibility. Furthermore, recent findings highlight the need for further research and development in active transistor arrays, including silicon, metal oxide, and solution-gated transistors. These active transistor arrays have the potential to unlock the capabilities of high-density, high-throughput µECoG devices and overcome the limitations of passive multielectrode arrays. The review explores the potential innovations and applications of µECoG devices, showcasing their effectiveness for both brain science research and clinical applications.http://www.sciencedirect.com/science/article/pii/S2667325824000402ElectrocorticographyMicro-electrocorticographyFlexible electronicsBioelectronicsNeural electrode array |
| spellingShingle | Yang Xie Yanxiu Peng Jinhong Guo Muyang Liu Bozhen Zhang Lan Yin He Ding Xing Sheng Materials and devices for high‐density, high‐throughput micro‐electrocorticography arrays Fundamental Research Electrocorticography Micro-electrocorticography Flexible electronics Bioelectronics Neural electrode array |
| title | Materials and devices for high‐density, high‐throughput micro‐electrocorticography arrays |
| title_full | Materials and devices for high‐density, high‐throughput micro‐electrocorticography arrays |
| title_fullStr | Materials and devices for high‐density, high‐throughput micro‐electrocorticography arrays |
| title_full_unstemmed | Materials and devices for high‐density, high‐throughput micro‐electrocorticography arrays |
| title_short | Materials and devices for high‐density, high‐throughput micro‐electrocorticography arrays |
| title_sort | materials and devices for high density high throughput micro electrocorticography arrays |
| topic | Electrocorticography Micro-electrocorticography Flexible electronics Bioelectronics Neural electrode array |
| url | http://www.sciencedirect.com/science/article/pii/S2667325824000402 |
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