Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1.

Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1.

Myeloid cell and hepatocyte IKKβ may mediate the genesis of obesity and insulin resistance in mice fed high fat diet. However, their gender-specific roles in the pathogenesis of non-alcoholic steatohepatitis (NASH) are not known. Here we demonstrate myeloid IKKβ deficiency prevents Western diet-indu...

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Bibliographic Details
Main Authors: Noriko Matsushita, Mohamed T Hassanein, Marcos Martinez-Clemente, Raul Lazaro, Samuel W French, Wen Xie, Keane Lai, Michael Karin, Hidekazu Tsukamoto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181052&type=printable
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