Anti-diabetic Activity of Phloretin Against Maltase-glucoamylase Using Docking, Pharmacokinetics and Pharmacophore Studies
A metabolic condition known as diabetes mellitus is characterized by hyperglycemia brought on by either inadequate insulin production, resistance to insulin action, or both. The anti-diabetic medications that are now on the market either impact how much glucose is absorbed and excreted or how much i...
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| Format: | Article |
| Language: | English |
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Iranian Chemical Science and Technologies Association
2023-10-01
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| Series: | Journal of Chemistry Letters |
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| Online Access: | https://www.jchemlett.com/article_180463_a98d8d21bd62de90ef55db0f9a0c099f.pdf |
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| author | Miah Roney Mohd Fadhlizil Fasihi Mohd Aluwi |
| author_facet | Miah Roney Mohd Fadhlizil Fasihi Mohd Aluwi |
| author_sort | Miah Roney |
| collection | DOAJ |
| description | A metabolic condition known as diabetes mellitus is characterized by hyperglycemia brought on by either inadequate insulin production, resistance to insulin action, or both. The anti-diabetic medications that are now on the market either impact how much glucose is absorbed and excreted or how much insulin is secreted without affecting insulin resistance. This study used in-silico methods to assess the efficacy of phloretin as anti-diabetic drug against maltase-glucoamylase. Phloretin displayed strong binding to the maltase-glucoamylase protein with good docking scores (-7.4 kcal/mol), as opposed to co-crystallized ligand (-6.2 kcal/mol). In terms of physicochemical qualities, drug-likeness, and medicinal chemistry properties, Phloretin also performed best. The results of molecular docking and data acquired from pharmacokinetic characteristics of phloretin may be used further for the creation of newer maltase-glucoamylases with potential anti-diabetic properties and improved pharmacokinetic profiles. |
| format | Article |
| id | doaj-art-af03f5b5e66e4728aba1f497708d0ce0 |
| institution | DOAJ |
| issn | 2821-0123 2717-1892 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Iranian Chemical Science and Technologies Association |
| record_format | Article |
| series | Journal of Chemistry Letters |
| spelling | doaj-art-af03f5b5e66e4728aba1f497708d0ce02025-08-20T03:16:46ZengIranian Chemical Science and Technologies AssociationJournal of Chemistry Letters2821-01232717-18922023-10-014316417010.22034/jchemlett.2023.411216.1131180463Anti-diabetic Activity of Phloretin Against Maltase-glucoamylase Using Docking, Pharmacokinetics and Pharmacophore StudiesMiah Roney0Mohd Fadhlizil Fasihi Mohd Aluwi1Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang Al-Sultan Abdullah, Gambang-26300, Kuantan, Pahang, MalaysiaFaculty of Industrial Sciences and Technology, Universiti Malaysia Pahang Al-Sultan Abdullah, Gambang (26300), Kuantan, Pahang, MalaysiaA metabolic condition known as diabetes mellitus is characterized by hyperglycemia brought on by either inadequate insulin production, resistance to insulin action, or both. The anti-diabetic medications that are now on the market either impact how much glucose is absorbed and excreted or how much insulin is secreted without affecting insulin resistance. This study used in-silico methods to assess the efficacy of phloretin as anti-diabetic drug against maltase-glucoamylase. Phloretin displayed strong binding to the maltase-glucoamylase protein with good docking scores (-7.4 kcal/mol), as opposed to co-crystallized ligand (-6.2 kcal/mol). In terms of physicochemical qualities, drug-likeness, and medicinal chemistry properties, Phloretin also performed best. The results of molecular docking and data acquired from pharmacokinetic characteristics of phloretin may be used further for the creation of newer maltase-glucoamylases with potential anti-diabetic properties and improved pharmacokinetic profiles.https://www.jchemlett.com/article_180463_a98d8d21bd62de90ef55db0f9a0c099f.pdfin-silicodockingpharmacophore |
| spellingShingle | Miah Roney Mohd Fadhlizil Fasihi Mohd Aluwi Anti-diabetic Activity of Phloretin Against Maltase-glucoamylase Using Docking, Pharmacokinetics and Pharmacophore Studies Journal of Chemistry Letters in-silico docking pharmacophore |
| title | Anti-diabetic Activity of Phloretin Against Maltase-glucoamylase Using Docking, Pharmacokinetics and Pharmacophore Studies |
| title_full | Anti-diabetic Activity of Phloretin Against Maltase-glucoamylase Using Docking, Pharmacokinetics and Pharmacophore Studies |
| title_fullStr | Anti-diabetic Activity of Phloretin Against Maltase-glucoamylase Using Docking, Pharmacokinetics and Pharmacophore Studies |
| title_full_unstemmed | Anti-diabetic Activity of Phloretin Against Maltase-glucoamylase Using Docking, Pharmacokinetics and Pharmacophore Studies |
| title_short | Anti-diabetic Activity of Phloretin Against Maltase-glucoamylase Using Docking, Pharmacokinetics and Pharmacophore Studies |
| title_sort | anti diabetic activity of phloretin against maltase glucoamylase using docking pharmacokinetics and pharmacophore studies |
| topic | in-silico docking pharmacophore |
| url | https://www.jchemlett.com/article_180463_a98d8d21bd62de90ef55db0f9a0c099f.pdf |
| work_keys_str_mv | AT miahroney antidiabeticactivityofphloretinagainstmaltaseglucoamylaseusingdockingpharmacokineticsandpharmacophorestudies AT mohdfadhlizilfasihimohdaluwi antidiabeticactivityofphloretinagainstmaltaseglucoamylaseusingdockingpharmacokineticsandpharmacophorestudies |