Successful Long-Term Use of Infliximab in Refractory Pouchitis in an Adolescent
Pouchitis is a common complication that develops after an ileal pouch-anal anastomosis after colectomy for ulcerative colitis. In some cases, pouchitis becomes chronic and refractory to conventional therapies including antibiotics, corticosteroids, immunomodulators, probiotics, and anti-inflammatory...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/860394 |
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| _version_ | 1850160100602281984 |
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| author | Jessica Yeates Mohsin Rashid |
| author_facet | Jessica Yeates Mohsin Rashid |
| author_sort | Jessica Yeates |
| collection | DOAJ |
| description | Pouchitis is a common complication that develops after an ileal pouch-anal anastomosis after colectomy for ulcerative colitis. In some cases, pouchitis becomes chronic and refractory to conventional therapies including antibiotics, corticosteroids, immunomodulators, probiotics, and anti-inflammatory drugs. We report a case of an adolescent with chronic pouchitis who not only improved with infliximab therapy but remains in long-term remission with maintenance therapy without any adverse effects. Infliximab is a safe and effective therapy for refractory pouchitis and may obviate the need for pouch removal and a permanent ileostomy. |
| format | Article |
| id | doaj-art-af03e7150fc64e76abedee550e9b09ee |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-af03e7150fc64e76abedee550e9b09ee2025-08-20T02:23:15ZengWileyGastroenterology Research and Practice1687-61211687-630X2010-01-01201010.1155/2010/860394860394Successful Long-Term Use of Infliximab in Refractory Pouchitis in an AdolescentJessica Yeates0Mohsin Rashid1Division of Gastroenterology and Nutrition, Department of Paediatrics, Faculty of Medicine, Dalhousie University, IWK Health Centre, 5850 University Avenue, Halifax, NS, B3K 6R8, CanadaDivision of Gastroenterology and Nutrition, Department of Paediatrics, Faculty of Medicine, Dalhousie University, IWK Health Centre, 5850 University Avenue, Halifax, NS, B3K 6R8, CanadaPouchitis is a common complication that develops after an ileal pouch-anal anastomosis after colectomy for ulcerative colitis. In some cases, pouchitis becomes chronic and refractory to conventional therapies including antibiotics, corticosteroids, immunomodulators, probiotics, and anti-inflammatory drugs. We report a case of an adolescent with chronic pouchitis who not only improved with infliximab therapy but remains in long-term remission with maintenance therapy without any adverse effects. Infliximab is a safe and effective therapy for refractory pouchitis and may obviate the need for pouch removal and a permanent ileostomy.http://dx.doi.org/10.1155/2010/860394 |
| spellingShingle | Jessica Yeates Mohsin Rashid Successful Long-Term Use of Infliximab in Refractory Pouchitis in an Adolescent Gastroenterology Research and Practice |
| title | Successful Long-Term Use of Infliximab in Refractory Pouchitis in an Adolescent |
| title_full | Successful Long-Term Use of Infliximab in Refractory Pouchitis in an Adolescent |
| title_fullStr | Successful Long-Term Use of Infliximab in Refractory Pouchitis in an Adolescent |
| title_full_unstemmed | Successful Long-Term Use of Infliximab in Refractory Pouchitis in an Adolescent |
| title_short | Successful Long-Term Use of Infliximab in Refractory Pouchitis in an Adolescent |
| title_sort | successful long term use of infliximab in refractory pouchitis in an adolescent |
| url | http://dx.doi.org/10.1155/2010/860394 |
| work_keys_str_mv | AT jessicayeates successfullongtermuseofinfliximabinrefractorypouchitisinanadolescent AT mohsinrashid successfullongtermuseofinfliximabinrefractorypouchitisinanadolescent |