How the ghrelin receptor recognizes the acyl-modified orexigenic hormone

How the ghrelin receptor recognizes the acyl-modified orexigenic hormone

Ghrelin, discovered in 1999 as an endogenous ligand of the growth hormone secretagogue receptor (now known as the ghrelin receptor), is a peptide hormone with diverse physiological activities, such as stimulation of growth hormone release, increased appetite, fat accumulation, thermoregulation, and...

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Bibliographic Details
Main Authors: Yuki Shiimura, Masayasu Kojima, Takahiro Sato
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
ghrelin
ghrelin receptor (GHS-R1a)
GPCR
structural biochemistry
orexigenic hormone
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2025.1549366/full
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