Spectrophotometric Determination of Raloxifene Hydrochloride in Pharmaceutical Formulations
Three new simple, sensitive, rapid and economical spectrophotometric Methods (A, B and C) have been developed for the determination of Raloxifene Hydrochloride in pharmaceutical bulk and tablet dosage form. Method A is based on the formation of yellow colored chromogen with 0.1N Sodium hydroxide exh...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2007/480625 |
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| author | M. Mathrusri Annapurna M. E. Bhanoji Rao B. V. V. Ravi Kumar |
| author_facet | M. Mathrusri Annapurna M. E. Bhanoji Rao B. V. V. Ravi Kumar |
| author_sort | M. Mathrusri Annapurna |
| collection | DOAJ |
| description | Three new simple, sensitive, rapid and economical spectrophotometric Methods (A, B and C) have been developed for the determination of Raloxifene Hydrochloride in pharmaceutical bulk and tablet dosage form. Method A is based on the formation of yellow colored chromogen with 0.1N Sodium hydroxide exhibiting maximum absorbance against the corresponding reagent blank. The method B is based on the reaction of Raloxifene with Ferric chloride and 1, 10-phenanthroline to form blood red colored chromogen. The method C is based on the formation of blood red colored chromogen with Ferric chloride and 2, 2' bipyridyl. The absorbencies of the chromogens were measured at their respective wavelength of maximum absorbance against the corresponding reagent blank. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and accurate. |
| format | Article |
| id | doaj-art-aefd4cd6ca334fff81bb128deffd2434 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-aefd4cd6ca334fff81bb128deffd24342025-02-03T05:45:04ZengWileyE-Journal of Chemistry0973-49452090-98102007-01-0141798210.1155/2007/480625Spectrophotometric Determination of Raloxifene Hydrochloride in Pharmaceutical FormulationsM. Mathrusri Annapurna0M. E. Bhanoji Rao1B. V. V. Ravi Kumar2Department of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Ambapua, Berhampur, Orissa-760010, IndiaDepartment of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Ambapua, Berhampur, Orissa-760010, IndiaDepartment of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Ambapua, Berhampur, Orissa-760010, IndiaThree new simple, sensitive, rapid and economical spectrophotometric Methods (A, B and C) have been developed for the determination of Raloxifene Hydrochloride in pharmaceutical bulk and tablet dosage form. Method A is based on the formation of yellow colored chromogen with 0.1N Sodium hydroxide exhibiting maximum absorbance against the corresponding reagent blank. The method B is based on the reaction of Raloxifene with Ferric chloride and 1, 10-phenanthroline to form blood red colored chromogen. The method C is based on the formation of blood red colored chromogen with Ferric chloride and 2, 2' bipyridyl. The absorbencies of the chromogens were measured at their respective wavelength of maximum absorbance against the corresponding reagent blank. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and accurate.http://dx.doi.org/10.1155/2007/480625 |
| spellingShingle | M. Mathrusri Annapurna M. E. Bhanoji Rao B. V. V. Ravi Kumar Spectrophotometric Determination of Raloxifene Hydrochloride in Pharmaceutical Formulations E-Journal of Chemistry |
| title | Spectrophotometric Determination of Raloxifene Hydrochloride in Pharmaceutical Formulations |
| title_full | Spectrophotometric Determination of Raloxifene Hydrochloride in Pharmaceutical Formulations |
| title_fullStr | Spectrophotometric Determination of Raloxifene Hydrochloride in Pharmaceutical Formulations |
| title_full_unstemmed | Spectrophotometric Determination of Raloxifene Hydrochloride in Pharmaceutical Formulations |
| title_short | Spectrophotometric Determination of Raloxifene Hydrochloride in Pharmaceutical Formulations |
| title_sort | spectrophotometric determination of raloxifene hydrochloride in pharmaceutical formulations |
| url | http://dx.doi.org/10.1155/2007/480625 |
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