Benzyl isothiocyanate provokes senolysis by targeting AKT in senescent IPF fibroblasts and reverses persistent pulmonary fibrosis in aged mice

Benzyl isothiocyanate provokes senolysis by targeting AKT in senescent IPF fibroblasts and reverses persistent pulmonary fibrosis in aged mice

IntroductionSenescent cells (SCs) accumulate with age and play a causative role in age-related diseases, such as idiopathic pulmonary fibrosis (IPF). Clearance of SCs attenuates lung fibrogenesis and favors fibrosis resolution, suggesting that targeting of SCs is recognized as a promising therapeuti...

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Bibliographic Details
Main Authors: Rui Wang, Fan Yang, Ying Liu, Meiting Peng, Lu Yu, Qinhui Hou, Yuan Liu, Zhenshun Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
idiopathic pulmonary fibrosis
cellular senescence
senolysis
benzyl isothiocyanate
fibroblasts
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1506518/full
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