Intravitreal injection of TA-III with sustained release to simultaneously impart anti-inflammatory, antioxidative, and vascular remodeling activities in diabetic retinopathy

Intravitreal injection of TA-III with sustained release to simultaneously impart anti-inflammatory, antioxidative, and vascular remodeling activities in diabetic retinopathy

Diabetes negatively impacts vision and retinal function. However, current therapeutic options for diabetic retinopathy (DR) often present limitations, including targeting specific pathways, short duration of action, and need for frequent injections. Timosaponin AIII (TA-III) exhibited the potential...

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Bibliographic Details
Main Authors: Jie Zhang, Yu Liu, Yu Gong, Yanyu Shangguan, Pengli Wang, Yanlong Bi, Yong Xu, Bo Tao, Bing Li
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Materials & Design
Subjects:
Diabetic retinopathy
Timosaponin AIII
Hydrogel
Anti-inflammation
Anti-oxidative stress
Vascular remodeling
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127525002527
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