Comparative efficacy of targeted therapy, chemotherapy and their combination for advanced cholangiocarcinoma: a systematic review and network meta-analysis
Background Cholangiocarcinoma is a malignant tumor with a poor prognosis. Multiple randomized controlled trial (RCT) have shown conflicting benefits of different therapies. The study was to assess the effectiveness of chemotherapy (CT), targeted therapy (TT) and both of them (targeted therapy + chem...
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PeerJ Inc.
2025-05-01
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| author | Zhoujun Liao Zhuoyue Yao Zhiqing Yang Shaohua Yang Wenjuan Gu Huijie Wang Lingyan Deng |
| author_facet | Zhoujun Liao Zhuoyue Yao Zhiqing Yang Shaohua Yang Wenjuan Gu Huijie Wang Lingyan Deng |
| author_sort | Zhoujun Liao |
| collection | DOAJ |
| description | Background Cholangiocarcinoma is a malignant tumor with a poor prognosis. Multiple randomized controlled trial (RCT) have shown conflicting benefits of different therapies. The study was to assess the effectiveness of chemotherapy (CT), targeted therapy (TT) and both of them (targeted therapy + chemotherapy; TT+CT) for advanced cholangiocarcinoma by a systematic review and network meta-analysis. Methods PubMed, EmBase, Medline, Cochrane were searched. Two reviewers independently selected published reports of RCT comparing any targeted therapy, chemotherapy and targeted therapy combined with chemotherapy vs. placebo. The outcomes were overall survival (OS) and progression-free survival (PFS) on the hazard ratio-scale (HR) and mean differences-scale (MD). Results We included 13 RCT involving 1,914 patients. We revealed a differential reporting of outcomes. All three treatments significantly reduced the HR in OS and PFS when compared with the placebo. HR and MD values of OS and PFS in TT+CT group were significantly better than those in the other two groups. Only targeted therapy can significantly improve PFS in patients. Conclusions 1) All treatments significantly reduced the hazard ratio in OS and PFS when compared with the placebo; 2) HR and MD values of OS and PFS in TT+CT group were significantly better; 3) Only targeted therapy alone significantly increased the PFS of patients, thereby improving the quality of life of patients. |
| format | Article |
| id | doaj-art-aef908b4728248a3a97bc9dbac24dc67 |
| institution | Kabale University |
| issn | 2167-8359 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | PeerJ Inc. |
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| spelling | doaj-art-aef908b4728248a3a97bc9dbac24dc672025-08-20T03:49:37ZengPeerJ Inc.PeerJ2167-83592025-05-0113e1938610.7717/peerj.19386Comparative efficacy of targeted therapy, chemotherapy and their combination for advanced cholangiocarcinoma: a systematic review and network meta-analysisZhoujun Liao0Zhuoyue Yao1Zhiqing Yang2Shaohua Yang3Wenjuan Gu4Huijie Wang5Lingyan Deng6Department of General Surgery, Panzhihua College Affiliated Hospital, Panzhihua University, Panzhihua, Panzhihua, ChinaBeijing TianTan Hospital, Beijing, ChinaJiangxi Dexing Hospital, Shangrao, ChinaThe First People’s Hospital of Qujing City, Qujing, ChinaTianjin Kanghui Hospital, Tianjin, ChinaJincheng People’s Hospital of Shanxi Province, Jincheng, ChinaMaternal and Child Healthcare Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaBackground Cholangiocarcinoma is a malignant tumor with a poor prognosis. Multiple randomized controlled trial (RCT) have shown conflicting benefits of different therapies. The study was to assess the effectiveness of chemotherapy (CT), targeted therapy (TT) and both of them (targeted therapy + chemotherapy; TT+CT) for advanced cholangiocarcinoma by a systematic review and network meta-analysis. Methods PubMed, EmBase, Medline, Cochrane were searched. Two reviewers independently selected published reports of RCT comparing any targeted therapy, chemotherapy and targeted therapy combined with chemotherapy vs. placebo. The outcomes were overall survival (OS) and progression-free survival (PFS) on the hazard ratio-scale (HR) and mean differences-scale (MD). Results We included 13 RCT involving 1,914 patients. We revealed a differential reporting of outcomes. All three treatments significantly reduced the HR in OS and PFS when compared with the placebo. HR and MD values of OS and PFS in TT+CT group were significantly better than those in the other two groups. Only targeted therapy can significantly improve PFS in patients. Conclusions 1) All treatments significantly reduced the hazard ratio in OS and PFS when compared with the placebo; 2) HR and MD values of OS and PFS in TT+CT group were significantly better; 3) Only targeted therapy alone significantly increased the PFS of patients, thereby improving the quality of life of patients.https://peerj.com/articles/19386.pdfSystematic reviewComparative effectiveness reviewAdvanced cholangiocarcinomaChemotherapyTargeted therapy |
| spellingShingle | Zhoujun Liao Zhuoyue Yao Zhiqing Yang Shaohua Yang Wenjuan Gu Huijie Wang Lingyan Deng Comparative efficacy of targeted therapy, chemotherapy and their combination for advanced cholangiocarcinoma: a systematic review and network meta-analysis PeerJ Systematic review Comparative effectiveness review Advanced cholangiocarcinoma Chemotherapy Targeted therapy |
| title | Comparative efficacy of targeted therapy, chemotherapy and their combination for advanced cholangiocarcinoma: a systematic review and network meta-analysis |
| title_full | Comparative efficacy of targeted therapy, chemotherapy and their combination for advanced cholangiocarcinoma: a systematic review and network meta-analysis |
| title_fullStr | Comparative efficacy of targeted therapy, chemotherapy and their combination for advanced cholangiocarcinoma: a systematic review and network meta-analysis |
| title_full_unstemmed | Comparative efficacy of targeted therapy, chemotherapy and their combination for advanced cholangiocarcinoma: a systematic review and network meta-analysis |
| title_short | Comparative efficacy of targeted therapy, chemotherapy and their combination for advanced cholangiocarcinoma: a systematic review and network meta-analysis |
| title_sort | comparative efficacy of targeted therapy chemotherapy and their combination for advanced cholangiocarcinoma a systematic review and network meta analysis |
| topic | Systematic review Comparative effectiveness review Advanced cholangiocarcinoma Chemotherapy Targeted therapy |
| url | https://peerj.com/articles/19386.pdf |
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