Congenital Bands with Intestinal Malrotation after Propylthiouracil Exposure in Early Pregnancy
Exposure to propylthiouracil in early pregnancy may be associated with an increased risk of birth defects. But the spectrum of associated congenital anomalies is not yet well defined. While preliminary reports suggest that most cases of propylthiouracil-associated birth defects are restricted to the...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/789762 |
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| author | Alexander A. Leung Jennifer Yamamoto Paola Luca Paul Beaudry Julie McKeen |
| author_facet | Alexander A. Leung Jennifer Yamamoto Paola Luca Paul Beaudry Julie McKeen |
| author_sort | Alexander A. Leung |
| collection | DOAJ |
| description | Exposure to propylthiouracil in early pregnancy may be associated with an increased risk of birth defects. But the spectrum of associated congenital anomalies is not yet well defined. While preliminary reports suggest that most cases of propylthiouracil-associated birth defects are restricted to the preauricular and urinary systems, careful consideration should be given to other possible manifestations of teratogenicity. We propose that congenital bands may potentially represent a rare yet serious complication of propylthiouracil exposure in early pregnancy, possibly arising from an early mesenteric developmental anomaly. We report a case of a 17-day-old girl that presented with acute small bowel obstruction associated with intestinal malrotation arising from several anomalous congenital bands. Her mother was treated for Graves’ disease during pregnancy with first trimester exposure to propylthiouracil but remained clinically and biochemically euthyroid at conception and throughout the duration of pregnancy. This case suggests that the use of propylthiouracil in early pregnancy may be associated with congenital bands and intestinal malrotation. More reports are needed to further support this association. |
| format | Article |
| id | doaj-art-aef68ddcc1ea4febaec978dcdebb0b08 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-aef68ddcc1ea4febaec978dcdebb0b082025-02-03T05:51:58ZengWileyCase Reports in Endocrinology2090-65012090-651X2015-01-01201510.1155/2015/789762789762Congenital Bands with Intestinal Malrotation after Propylthiouracil Exposure in Early PregnancyAlexander A. Leung0Jennifer Yamamoto1Paola Luca2Paul Beaudry3Julie McKeen4Division of Endocrinology and Metabolism, Department of Medicine, University of Calgary, Calgary, AB, T2T 5C7, CanadaDivision of Endocrinology and Metabolism, Department of Medicine, University of Calgary, Calgary, AB, T2T 5C7, CanadaDivision of Endocrinology and Metabolism, Department of Pediatrics, University of Calgary, Calgary, AB, T3B 6A9, CanadaDivision of Pediatric Surgery, Department of Surgery, University of Calgary, Calgary, AB, T3B 6A9, CanadaDivision of Endocrinology and Metabolism, Department of Medicine, University of Calgary, Calgary, AB, T2T 5C7, CanadaExposure to propylthiouracil in early pregnancy may be associated with an increased risk of birth defects. But the spectrum of associated congenital anomalies is not yet well defined. While preliminary reports suggest that most cases of propylthiouracil-associated birth defects are restricted to the preauricular and urinary systems, careful consideration should be given to other possible manifestations of teratogenicity. We propose that congenital bands may potentially represent a rare yet serious complication of propylthiouracil exposure in early pregnancy, possibly arising from an early mesenteric developmental anomaly. We report a case of a 17-day-old girl that presented with acute small bowel obstruction associated with intestinal malrotation arising from several anomalous congenital bands. Her mother was treated for Graves’ disease during pregnancy with first trimester exposure to propylthiouracil but remained clinically and biochemically euthyroid at conception and throughout the duration of pregnancy. This case suggests that the use of propylthiouracil in early pregnancy may be associated with congenital bands and intestinal malrotation. More reports are needed to further support this association.http://dx.doi.org/10.1155/2015/789762 |
| spellingShingle | Alexander A. Leung Jennifer Yamamoto Paola Luca Paul Beaudry Julie McKeen Congenital Bands with Intestinal Malrotation after Propylthiouracil Exposure in Early Pregnancy Case Reports in Endocrinology |
| title | Congenital Bands with Intestinal Malrotation after Propylthiouracil Exposure in Early Pregnancy |
| title_full | Congenital Bands with Intestinal Malrotation after Propylthiouracil Exposure in Early Pregnancy |
| title_fullStr | Congenital Bands with Intestinal Malrotation after Propylthiouracil Exposure in Early Pregnancy |
| title_full_unstemmed | Congenital Bands with Intestinal Malrotation after Propylthiouracil Exposure in Early Pregnancy |
| title_short | Congenital Bands with Intestinal Malrotation after Propylthiouracil Exposure in Early Pregnancy |
| title_sort | congenital bands with intestinal malrotation after propylthiouracil exposure in early pregnancy |
| url | http://dx.doi.org/10.1155/2015/789762 |
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