Upstream open reading frames dynamically modulate CLOCK protein translation to regulate circadian rhythms and sleep.

Upstream open reading frames dynamically modulate CLOCK protein translation to regulate circadian rhythms and sleep.

The circadian rhythm is an evolutionarily conserved mechanism with translational regulation increasingly recognized as pivotal in its modulation. In this study, we found that upstream open reading frames (uORFs) are enriched in Drosophila circadian rhythm genes, with particularly conserved uORFs pre...

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Main Authors: Yuanqiang Sun, Ke Shui, Qinyu Li, Chenlu Liu, Wanting Jin, Jian-Quan Ni, Jian Lu, Luoying Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-05-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3003173
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https://doi.org/10.1371/journal.pbio.3003173

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