CAFs exosomal miR-21-5p suppresses ferroptosis and promotes proliferation and migration in osteosarcoma

CAFs exosomal miR-21-5p suppresses ferroptosis and promotes proliferation and migration in osteosarcoma

Abstract Background Osteosarcoma is one of the malignant tumors in children and adolescents patients. Uncontrolled and unlimited proliferation and metastasis lead to poor overall survival. CAFs play a pivotal role in the osteosarcoma tumor microenvironment, exerting significant influence on prognosi...

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Bibliographic Details
Main Authors: Xiaoying Niu, Wen Tian, Yuanmeng Ke, Yifan Li, Xinxin Zhang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cancer Cell International
Subjects:
Osteosarcoma
Proliferation
Migration
CAFs
Exosomal miR-21-5p
Ferroptosis
Online Access:https://doi.org/10.1186/s12935-025-03930-8
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