An Unusual Cause of Bleeding in a Patient with Chronic Myeloid Leukemia Chronic Phase
Chronic myelogenous leukemia (CML) is a clonal myeloproliferative neoplasm (MPN) characterized by dysregulated and uncontrolled proliferation of mature and maturing granulocytes with normal differentiation. A genetic hallmark of CML is the presence of the fusion gene product BCR-ABL. Bleeding diathe...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/5674193 |
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| author | S. Kartthik Prakas K. Mandal Saleh Mohammed Abdullah |
| author_facet | S. Kartthik Prakas K. Mandal Saleh Mohammed Abdullah |
| author_sort | S. Kartthik |
| collection | DOAJ |
| description | Chronic myelogenous leukemia (CML) is a clonal myeloproliferative neoplasm (MPN) characterized by dysregulated and uncontrolled proliferation of mature and maturing granulocytes with normal differentiation. A genetic hallmark of CML is the presence of the fusion gene product BCR-ABL. Bleeding diathesis in CML patients is rare (<10%) and primarily caused by acquired platelet dysfunction. We report a rare case of an adult CML chronic phase patient who presented with spontaneous muscle hematoma due to acquired Glanzmann’s thrombasthenia (GT). On laboratory workup, a GT was confirmed along with the diagnosis of CML in chronic phase. The muscle hematoma was completely resolved following imatinib therapy. The present case demonstrates that bleeding is a complication of MPNs and highlights the importance of both acquired GT diagnosis to determine the cause of bleeding in CML and of prompt treatment with imatinib to reverse this condition. |
| format | Article |
| id | doaj-art-aeef332ece3642e2bd5d041b2ec0fd0d |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-aeef332ece3642e2bd5d041b2ec0fd0d2025-08-20T03:39:04ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/56741935674193An Unusual Cause of Bleeding in a Patient with Chronic Myeloid Leukemia Chronic PhaseS. Kartthik0Prakas K. Mandal1Saleh Mohammed Abdullah2Department of Haematology–Oncology, GKNM Hospital, Coimbatore, Tamilnadu, IndiaDepartment of Haematology, NRS Medical College and Hospital, Kolkata, West Bengal, IndiaDepartment of Medical Laboratory, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi ArabiaChronic myelogenous leukemia (CML) is a clonal myeloproliferative neoplasm (MPN) characterized by dysregulated and uncontrolled proliferation of mature and maturing granulocytes with normal differentiation. A genetic hallmark of CML is the presence of the fusion gene product BCR-ABL. Bleeding diathesis in CML patients is rare (<10%) and primarily caused by acquired platelet dysfunction. We report a rare case of an adult CML chronic phase patient who presented with spontaneous muscle hematoma due to acquired Glanzmann’s thrombasthenia (GT). On laboratory workup, a GT was confirmed along with the diagnosis of CML in chronic phase. The muscle hematoma was completely resolved following imatinib therapy. The present case demonstrates that bleeding is a complication of MPNs and highlights the importance of both acquired GT diagnosis to determine the cause of bleeding in CML and of prompt treatment with imatinib to reverse this condition.http://dx.doi.org/10.1155/2019/5674193 |
| spellingShingle | S. Kartthik Prakas K. Mandal Saleh Mohammed Abdullah An Unusual Cause of Bleeding in a Patient with Chronic Myeloid Leukemia Chronic Phase Case Reports in Hematology |
| title | An Unusual Cause of Bleeding in a Patient with Chronic Myeloid Leukemia Chronic Phase |
| title_full | An Unusual Cause of Bleeding in a Patient with Chronic Myeloid Leukemia Chronic Phase |
| title_fullStr | An Unusual Cause of Bleeding in a Patient with Chronic Myeloid Leukemia Chronic Phase |
| title_full_unstemmed | An Unusual Cause of Bleeding in a Patient with Chronic Myeloid Leukemia Chronic Phase |
| title_short | An Unusual Cause of Bleeding in a Patient with Chronic Myeloid Leukemia Chronic Phase |
| title_sort | unusual cause of bleeding in a patient with chronic myeloid leukemia chronic phase |
| url | http://dx.doi.org/10.1155/2019/5674193 |
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