Evaluation of Novel Calcium Silicate-Based Sealers Reinforced with Bioactive Glass
Background: Calcium silicate-based sealers have gained significant attention in endodontics due to their biocompatibility, bioactivity, and sealing ability. Incorporating bioactive glass into these sealers could potentially enhance their physicochemical and biological properties, providing improved...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_101_25 |
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| author | Divya Batra Surya Dahiya Sunil Kar Ambuj Arora Ashtha Arya Ataul H. Imran |
| author_facet | Divya Batra Surya Dahiya Sunil Kar Ambuj Arora Ashtha Arya Ataul H. Imran |
| author_sort | Divya Batra |
| collection | DOAJ |
| description | Background:
Calcium silicate-based sealers have gained significant attention in endodontics due to their biocompatibility, bioactivity, and sealing ability. Incorporating bioactive glass into these sealers could potentially enhance their physicochemical and biological properties, providing improved clinical outcomes.
Materials and Methods:
Three experimental sealer groups were prepared: group A (calcium silicate-based sealer without reinforcement), group B (calcium silicate-based sealer with 10% bioactive glass), and group C (calcium silicate-based sealer with 20% bioactive glass). The sealers were assessed for their setting time, compressive strength, solubility, and bioactivity. Bioactivity was evaluated by immersing the sealers in simulated body fluid and analyzing hydroxyapatite formation using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). Statistical analysis was conducted using ANOVA with a significance level of P < 0.05.
Results:
Group C demonstrated the shortest setting time (20 ± 1.5 minutes) compared to group B (25 ± 1.2 minutes) and group A (30 ± 1.8 minutes). Compressive strength was significantly higher in group C (80 ± 5 MPa) than in group B (65 ± 4 MPa) and group A (50 ± 3 MPa). Solubility was lowest in group C (2.5 ± 0.3%) and highest in group A (4.5 ± 0.4%). SEM and EDS analysis revealed a greater formation of hydroxyapatite on the surface of group C, indicating superior bioactivity.
Conclusion:
The addition of bioactive glass to calcium silicate-based sealers significantly improved their mechanical properties, reduced solubility, and enhanced bioactivity. The findings suggest that these reinforced sealers could be promising candidates for endodontic applications, providing improved long-term sealing and biological outcomes. |
| format | Article |
| id | doaj-art-aeeec803aeb84d80a1c144d0040caaf1 |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-aeeec803aeb84d80a1c144d0040caaf12025-08-20T03:31:33ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-06-0117Suppl 2S1535S153710.4103/jpbs.jpbs_101_25Evaluation of Novel Calcium Silicate-Based Sealers Reinforced with Bioactive GlassDivya BatraSurya DahiyaSunil KarAmbuj AroraAshtha AryaAtaul H. ImranBackground: Calcium silicate-based sealers have gained significant attention in endodontics due to their biocompatibility, bioactivity, and sealing ability. Incorporating bioactive glass into these sealers could potentially enhance their physicochemical and biological properties, providing improved clinical outcomes. Materials and Methods: Three experimental sealer groups were prepared: group A (calcium silicate-based sealer without reinforcement), group B (calcium silicate-based sealer with 10% bioactive glass), and group C (calcium silicate-based sealer with 20% bioactive glass). The sealers were assessed for their setting time, compressive strength, solubility, and bioactivity. Bioactivity was evaluated by immersing the sealers in simulated body fluid and analyzing hydroxyapatite formation using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). Statistical analysis was conducted using ANOVA with a significance level of P < 0.05. Results: Group C demonstrated the shortest setting time (20 ± 1.5 minutes) compared to group B (25 ± 1.2 minutes) and group A (30 ± 1.8 minutes). Compressive strength was significantly higher in group C (80 ± 5 MPa) than in group B (65 ± 4 MPa) and group A (50 ± 3 MPa). Solubility was lowest in group C (2.5 ± 0.3%) and highest in group A (4.5 ± 0.4%). SEM and EDS analysis revealed a greater formation of hydroxyapatite on the surface of group C, indicating superior bioactivity. Conclusion: The addition of bioactive glass to calcium silicate-based sealers significantly improved their mechanical properties, reduced solubility, and enhanced bioactivity. The findings suggest that these reinforced sealers could be promising candidates for endodontic applications, providing improved long-term sealing and biological outcomes.https://journals.lww.com/10.4103/jpbs.jpbs_101_25bioactive glassbioactivitycalcium silicate-based sealersendodonticshydroxyapatitemechanical properties |
| spellingShingle | Divya Batra Surya Dahiya Sunil Kar Ambuj Arora Ashtha Arya Ataul H. Imran Evaluation of Novel Calcium Silicate-Based Sealers Reinforced with Bioactive Glass Journal of Pharmacy and Bioallied Sciences bioactive glass bioactivity calcium silicate-based sealers endodontics hydroxyapatite mechanical properties |
| title | Evaluation of Novel Calcium Silicate-Based Sealers Reinforced with Bioactive Glass |
| title_full | Evaluation of Novel Calcium Silicate-Based Sealers Reinforced with Bioactive Glass |
| title_fullStr | Evaluation of Novel Calcium Silicate-Based Sealers Reinforced with Bioactive Glass |
| title_full_unstemmed | Evaluation of Novel Calcium Silicate-Based Sealers Reinforced with Bioactive Glass |
| title_short | Evaluation of Novel Calcium Silicate-Based Sealers Reinforced with Bioactive Glass |
| title_sort | evaluation of novel calcium silicate based sealers reinforced with bioactive glass |
| topic | bioactive glass bioactivity calcium silicate-based sealers endodontics hydroxyapatite mechanical properties |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_101_25 |
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