Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis
Abstract Amino acid sensing in the central nervous system plays a key role in regulating energy homeostasis. The anterior piriform cortex (APC) has been implicated in sensing amino acid deficiency and rapidly inducing an aversive response. However, the precise types of neurons involved and whether t...
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Wiley
2025-07-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202502421 |
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| author | Peixiang Luo Kexin Tong Yeting Gan Min Tang Yuguo Niu Kan Liu Shihong Ni Shangming Wu Xiaoxue Jiang Haizhou Jiang Fei Xiao Shanghai Chen Wei Lv Xiaoying Li Feixiang Yuan Feifan Guo |
| author_facet | Peixiang Luo Kexin Tong Yeting Gan Min Tang Yuguo Niu Kan Liu Shihong Ni Shangming Wu Xiaoxue Jiang Haizhou Jiang Fei Xiao Shanghai Chen Wei Lv Xiaoying Li Feixiang Yuan Feifan Guo |
| author_sort | Peixiang Luo |
| collection | DOAJ |
| description | Abstract Amino acid sensing in the central nervous system plays a key role in regulating energy homeostasis. The anterior piriform cortex (APC) has been implicated in sensing amino acid deficiency and rapidly inducing an aversive response. However, the precise types of neurons involved and whether they possess additional metabolic regulatory functions remain to be elucidated. The study reveals that corticotropin‐releasing hormone (CRH) neurons in the APC (APCCRH neurons) are activated by a leucine‐deficient diet to modulate brown adipose tissue thermogenesis and that they regulate body temperature in response to leucine deprivation. The findings reveal that APCCRH neurons are sensitive to leucine‐deprivation signaling, with general control nonderepressive‐2 playing an essential role in enhancing their intrinsic excitability. Furthermore, APCCRH neurons project into the known hypothalamic thermoregulatory region of the lateral hypothalamus, and APCCRH–lateral hypothalamus circuits mediate leucine deprivation‐induced thermogenesis. Additionally, it is observed that thermogenic regulation by APCCRH neurons contributes to the maintenance of body temperature under cold exposure. Collectively, the findings identify a population of leucine‐sensing APCCRH neurons, and reveal the signals and circuits involved in their regulation of brown adipose tissue thermogenesis and their subsequent contribution to body temperature regulation and energy homeostasis. |
| format | Article |
| id | doaj-art-aeeeaabf468a41729fdbd5ea89e4996b |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-aeeeaabf468a41729fdbd5ea89e4996b2025-08-20T03:50:58ZengWileyAdvanced Science2198-38442025-07-011227n/an/a10.1002/advs.202502421Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue ThermogenesisPeixiang Luo0Kexin Tong1Yeting Gan2Min Tang3Yuguo Niu4Kan Liu5Shihong Ni6Shangming Wu7Xiaoxue Jiang8Haizhou Jiang9Fei Xiao10Shanghai Chen11Wei Lv12Xiaoying Li13Feixiang Yuan14Feifan Guo15Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Sciences Shanghai ChinaInstitute for Translational Brain Research State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science Fudan University Shanghai ChinaInstitute for Translational Brain Research State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science Fudan University Shanghai ChinaInstitute for Translational Brain Research State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science Fudan University Shanghai ChinaInstitute for Translational Brain Research State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science Fudan University Shanghai ChinaShanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Sciences Shanghai ChinaInstitute for Translational Brain Research State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science Fudan University Shanghai ChinaShanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Sciences Shanghai ChinaInstitute for Translational Brain Research State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science Fudan University Shanghai ChinaDepartment of Endocrinology and Metabolism Zhongshan Hospital Fudan University Shanghai ChinaDepartment of Endocrinology and Metabolism Zhongshan Hospital Fudan University Shanghai ChinaInstitute for Translational Brain Research State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science Fudan University Shanghai ChinaShanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Sciences Shanghai ChinaDepartment of Endocrinology and Metabolism Zhongshan Hospital Fudan University Shanghai ChinaDepartment of Endocrinology and Metabolism Zhongshan Hospital Fudan University Shanghai ChinaDepartment of Endocrinology and Metabolism Zhongshan Hospital Fudan University Shanghai ChinaAbstract Amino acid sensing in the central nervous system plays a key role in regulating energy homeostasis. The anterior piriform cortex (APC) has been implicated in sensing amino acid deficiency and rapidly inducing an aversive response. However, the precise types of neurons involved and whether they possess additional metabolic regulatory functions remain to be elucidated. The study reveals that corticotropin‐releasing hormone (CRH) neurons in the APC (APCCRH neurons) are activated by a leucine‐deficient diet to modulate brown adipose tissue thermogenesis and that they regulate body temperature in response to leucine deprivation. The findings reveal that APCCRH neurons are sensitive to leucine‐deprivation signaling, with general control nonderepressive‐2 playing an essential role in enhancing their intrinsic excitability. Furthermore, APCCRH neurons project into the known hypothalamic thermoregulatory region of the lateral hypothalamus, and APCCRH–lateral hypothalamus circuits mediate leucine deprivation‐induced thermogenesis. Additionally, it is observed that thermogenic regulation by APCCRH neurons contributes to the maintenance of body temperature under cold exposure. Collectively, the findings identify a population of leucine‐sensing APCCRH neurons, and reveal the signals and circuits involved in their regulation of brown adipose tissue thermogenesis and their subsequent contribution to body temperature regulation and energy homeostasis.https://doi.org/10.1002/advs.202502421amino acid‐sensinganterior piriform cortexbody temperature regulationbrown adipose tissue thermogenesiscorticotropin‐releasing hormone neurons |
| spellingShingle | Peixiang Luo Kexin Tong Yeting Gan Min Tang Yuguo Niu Kan Liu Shihong Ni Shangming Wu Xiaoxue Jiang Haizhou Jiang Fei Xiao Shanghai Chen Wei Lv Xiaoying Li Feixiang Yuan Feifan Guo Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis Advanced Science amino acid‐sensing anterior piriform cortex body temperature regulation brown adipose tissue thermogenesis corticotropin‐releasing hormone neurons |
| title | Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis |
| title_full | Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis |
| title_fullStr | Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis |
| title_full_unstemmed | Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis |
| title_short | Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis |
| title_sort | amino acid sensing neurons in the anterior piriform cortex control brown adipose tissue thermogenesis |
| topic | amino acid‐sensing anterior piriform cortex body temperature regulation brown adipose tissue thermogenesis corticotropin‐releasing hormone neurons |
| url | https://doi.org/10.1002/advs.202502421 |
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