ZD7288 ameliorates long-term cerebral ischemia reperfusion-induced deterioration of spatial memory by regulating the expressions of NMDA receptor subunits in rats

ZD7288 ameliorates long-term cerebral ischemia reperfusion-induced deterioration of spatial memory by regulating the expressions of NMDA receptor subunits in rats

Abstract To study the effect of inhibition of hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) on spatial memory with cerebral ischemia-reperfusion (IR) in rats, the middle cerebral artery occlusion was performed to induce the IR injury. ZD7288 (5 µg/µl) and MK-801 (100 µg/µl...

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Bibliographic Details
Main Authors: Zhi He, Xiao-Jiao Chu, Xiao-Li Zeng, Xiao-Xue Zhang, Jing Chen, Ke Wang, Yue Chen, Zi-Cheng Li, Bo Zhao
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Stroke
HCN channel
Z7288
NMDA receptor
Spatial memory
Hippocampus
Online Access:https://doi.org/10.1038/s41598-025-03172-8
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