A multifaceted microenvironment nanoregulator for targeted ovarian cancer therapy
The treatment of ovarian cancer is hindered by its insidious onset and rapid progression. Exosomes (EXOs) present a promising therapeutic strategy for ovarian cancer by modulating the tumor microenvironment. However, concerns regarding the biosafety of animal-derived EXOs pose significant challenges...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1584463/full |
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| author | Yizheng Zu Yizheng Zu Min Li Min Li Ruyue Li Ruyue Li Shaohan Ma Shaohan Ma Yu’e Yang Yu’e Yang Shun Zhang Yuan Ma Yuan Ma Tiantian Wu Chunfang Ha Chunfang Ha |
| author_facet | Yizheng Zu Yizheng Zu Min Li Min Li Ruyue Li Ruyue Li Shaohan Ma Shaohan Ma Yu’e Yang Yu’e Yang Shun Zhang Yuan Ma Yuan Ma Tiantian Wu Chunfang Ha Chunfang Ha |
| author_sort | Yizheng Zu |
| collection | DOAJ |
| description | The treatment of ovarian cancer is hindered by its insidious onset and rapid progression. Exosomes (EXOs) present a promising therapeutic strategy for ovarian cancer by modulating the tumor microenvironment. However, concerns regarding the biosafety of animal-derived EXOs pose significant challenges to the development of innovative formulations. In this study, we propose a universal strategy to engineer plant-derived EXOs as microenvironment nanoregulators for targeted ovarian cancer therapy. EXOs derived from ginger were purified, loaded with the natural bioactive compound curcumin (Cur) with high encapsulation efficiency, and functionalized with a tumor-targeting aptamer. Upon intravenous administration, the resulting multifaceted microenvironment nanoregulator, termed AGE@Cur, effectively accumulates at the tumor site and exerts a tumor-suppressive effect through remodeling the tumor microenvironment. This novel therapeutic platform not only addresses the limitations of animal-derived EXOs but also paves the way for the development of innovative microenvironment regulators in clinical applications. |
| format | Article |
| id | doaj-art-aee9d4d2494b48e285ffe0720b7b789a |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-aee9d4d2494b48e285ffe0720b7b789a2025-08-20T03:06:41ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-03-011610.3389/fphar.2025.15844631584463A multifaceted microenvironment nanoregulator for targeted ovarian cancer therapyYizheng Zu0Yizheng Zu1Min Li2Min Li3Ruyue Li4Ruyue Li5Shaohan Ma6Shaohan Ma7Yu’e Yang8Yu’e Yang9Shun Zhang10Yuan Ma11Yuan Ma12Tiantian Wu13Chunfang Ha14Chunfang Ha15General Hospital of Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, ChinaGeneral Hospital of Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, ChinaGeneral Hospital of Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, ChinaGeneral Hospital of Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, ChinaGeneral Hospital of Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, ChinaSchool of Pharmacy, Hainan Medical University, Haikou, ChinaGeneral Hospital of Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, ChinaSchool of Pharmacy, Hainan Medical University, Haikou, ChinaGeneral Hospital of Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, ChinaThe treatment of ovarian cancer is hindered by its insidious onset and rapid progression. Exosomes (EXOs) present a promising therapeutic strategy for ovarian cancer by modulating the tumor microenvironment. However, concerns regarding the biosafety of animal-derived EXOs pose significant challenges to the development of innovative formulations. In this study, we propose a universal strategy to engineer plant-derived EXOs as microenvironment nanoregulators for targeted ovarian cancer therapy. EXOs derived from ginger were purified, loaded with the natural bioactive compound curcumin (Cur) with high encapsulation efficiency, and functionalized with a tumor-targeting aptamer. Upon intravenous administration, the resulting multifaceted microenvironment nanoregulator, termed AGE@Cur, effectively accumulates at the tumor site and exerts a tumor-suppressive effect through remodeling the tumor microenvironment. This novel therapeutic platform not only addresses the limitations of animal-derived EXOs but also paves the way for the development of innovative microenvironment regulators in clinical applications.https://www.frontiersin.org/articles/10.3389/fphar.2025.1584463/fullplant-derived exosomestumor microenvironmentcurcumintargeted therapydrug delivery |
| spellingShingle | Yizheng Zu Yizheng Zu Min Li Min Li Ruyue Li Ruyue Li Shaohan Ma Shaohan Ma Yu’e Yang Yu’e Yang Shun Zhang Yuan Ma Yuan Ma Tiantian Wu Chunfang Ha Chunfang Ha A multifaceted microenvironment nanoregulator for targeted ovarian cancer therapy Frontiers in Pharmacology plant-derived exosomes tumor microenvironment curcumin targeted therapy drug delivery |
| title | A multifaceted microenvironment nanoregulator for targeted ovarian cancer therapy |
| title_full | A multifaceted microenvironment nanoregulator for targeted ovarian cancer therapy |
| title_fullStr | A multifaceted microenvironment nanoregulator for targeted ovarian cancer therapy |
| title_full_unstemmed | A multifaceted microenvironment nanoregulator for targeted ovarian cancer therapy |
| title_short | A multifaceted microenvironment nanoregulator for targeted ovarian cancer therapy |
| title_sort | multifaceted microenvironment nanoregulator for targeted ovarian cancer therapy |
| topic | plant-derived exosomes tumor microenvironment curcumin targeted therapy drug delivery |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1584463/full |
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