Novel ALK gene mutation in inflammatory myofibroblastic tumor of the thyroid: a case report

Novel ALK gene mutation in inflammatory myofibroblastic tumor of the thyroid: a case report

BackgroundInflammatory myofibroblastic tumor (IMT) is a rare soft tissue neoplasm, exceptionally uncommon in the thyroid. Approximately 50%–70% of IMT cases exhibit ALK gene rearrangements or fusions, while ALK point mutations are rare. We report a novel ALK gene mutation, ALK-R395H, in a case of th...

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Bibliographic Details
Main Authors: Yang Guangxu, Li Yao, Xie Jing, Liu Hongsheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
inflammatory myofibroblastic tumor
thyroid
ALK-positive
gene mutation
case report
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1616075/full
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