Pleckstrin-2 promotes the progression of colorectal cancer via YTHDF2-mediated TYMS mRNA stability

Pleckstrin-2 promotes the progression of colorectal cancer via YTHDF2-mediated TYMS mRNA stability

Abstract High expression of nucleotide synthetic enzyme thymidylate synthase (TYMS) is responsible for the resistance to fluorouracil (FU) treatment and worse survival in colorectal cancer (CRC). Herein, we revealed that pleckstrin-2 (PLEK2) cooperated with YTHDF2 to enhance TYMS mRNA stability in C...

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Bibliographic Details
Main Authors: Qian Zhou, Yanxia Li, Xiaomei Li, Shujing Zhang, Ying Wang, Zhuoran Li, Xia Wang, Yuan Li, Jingxin Li, Chunhua Lu, Yuemao Shen, Baobing Zhao
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Cellular and Molecular Life Sciences
Subjects:
Pleckstrin-2
YTHDF2
TYMS
Colorectal cancer
M6A modification
Online Access:https://doi.org/10.1007/s00018-025-05782-x
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