Predictive factors for readmission due to neonatal hyperbilirubinemia: A retrospective case-control study.

<h4>Objective</h4>Hyperbilirubinemia is a common cause of hospital readmission among neonates, but the factors contributing to post-discharge readmission remain unclear. Our study aimed to identify predictive factors associated with readmission for neonatal hyperbilirubinemia.<h4>M...

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Main Authors: Yueju Cai, Xiaolan Li, Ping Wang, Yanyan Song
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0320767
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author Yueju Cai
Xiaolan Li
Ping Wang
Yanyan Song
author_facet Yueju Cai
Xiaolan Li
Ping Wang
Yanyan Song
author_sort Yueju Cai
collection DOAJ
description <h4>Objective</h4>Hyperbilirubinemia is a common cause of hospital readmission among neonates, but the factors contributing to post-discharge readmission remain unclear. Our study aimed to identify predictive factors associated with readmission for neonatal hyperbilirubinemia.<h4>Methods</h4>This retrospective case-control study included 421 neonates born at ≥ 35 weeks of gestation with hyperbilirubinemia between January and December 2021. The neonates were divided into a readmission group and a control group, and logistic regression was used to identify predictive factors associated with readmission.<h4>Results</h4>Among the 421 neonates studied, 32 (7.6%) were readmitted. Logistic regression analysis identified preterm birth (<37 weeks), ABO hemolysis, Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency, and Total Serum Bilirubin (TSB) level at discharge as significant predictive factors for readmission due to hyperbilirubinemia in newborns. Additionally, a decrease in birth weight was significantly linked to an increased risk of readmission (OR = 0.998, P = 0.013), although the effect size was relatively small.<h4>Conclusions</h4>Prolonging hospitalization and implementing robust post-discharge monitoring may be essential for neonates with prematurity, ABO hemolysis, G6PD deficiency, or elevated TSB levels at discharge.
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spelling doaj-art-aee4d5ff6d5f49b4a6e305e3079fca5a2025-08-20T02:16:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01204e032076710.1371/journal.pone.0320767Predictive factors for readmission due to neonatal hyperbilirubinemia: A retrospective case-control study.Yueju CaiXiaolan LiPing WangYanyan Song<h4>Objective</h4>Hyperbilirubinemia is a common cause of hospital readmission among neonates, but the factors contributing to post-discharge readmission remain unclear. Our study aimed to identify predictive factors associated with readmission for neonatal hyperbilirubinemia.<h4>Methods</h4>This retrospective case-control study included 421 neonates born at ≥ 35 weeks of gestation with hyperbilirubinemia between January and December 2021. The neonates were divided into a readmission group and a control group, and logistic regression was used to identify predictive factors associated with readmission.<h4>Results</h4>Among the 421 neonates studied, 32 (7.6%) were readmitted. Logistic regression analysis identified preterm birth (<37 weeks), ABO hemolysis, Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency, and Total Serum Bilirubin (TSB) level at discharge as significant predictive factors for readmission due to hyperbilirubinemia in newborns. Additionally, a decrease in birth weight was significantly linked to an increased risk of readmission (OR = 0.998, P = 0.013), although the effect size was relatively small.<h4>Conclusions</h4>Prolonging hospitalization and implementing robust post-discharge monitoring may be essential for neonates with prematurity, ABO hemolysis, G6PD deficiency, or elevated TSB levels at discharge.https://doi.org/10.1371/journal.pone.0320767
spellingShingle Yueju Cai
Xiaolan Li
Ping Wang
Yanyan Song
Predictive factors for readmission due to neonatal hyperbilirubinemia: A retrospective case-control study.
PLoS ONE
title Predictive factors for readmission due to neonatal hyperbilirubinemia: A retrospective case-control study.
title_full Predictive factors for readmission due to neonatal hyperbilirubinemia: A retrospective case-control study.
title_fullStr Predictive factors for readmission due to neonatal hyperbilirubinemia: A retrospective case-control study.
title_full_unstemmed Predictive factors for readmission due to neonatal hyperbilirubinemia: A retrospective case-control study.
title_short Predictive factors for readmission due to neonatal hyperbilirubinemia: A retrospective case-control study.
title_sort predictive factors for readmission due to neonatal hyperbilirubinemia a retrospective case control study
url https://doi.org/10.1371/journal.pone.0320767
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AT yanyansong predictivefactorsforreadmissionduetoneonatalhyperbilirubinemiaaretrospectivecasecontrolstudy