Relationship between glucose response curve shape during the oral glucose tolerance test and macrovascular complications in type 2 diabetes mellitus
Abstract Introduction This study evaluated the predictive value of glucose response curve shape during the oral glucose tolerance test (OGTT) for macrovascular complications in patients with type 2 diabetes mellitus (T2DM). Research design and methods A retrospective observational analysis was condu...
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BMC
2025-07-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-025-01867-6 |
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| author | Rong Ouyang Han Zhang Xiaoqin Zhao Renyue Hu Yi Sun Wei Chen Chen Qian Yunjuan Gu Xinlei Wang |
| author_facet | Rong Ouyang Han Zhang Xiaoqin Zhao Renyue Hu Yi Sun Wei Chen Chen Qian Yunjuan Gu Xinlei Wang |
| author_sort | Rong Ouyang |
| collection | DOAJ |
| description | Abstract Introduction This study evaluated the predictive value of glucose response curve shape during the oral glucose tolerance test (OGTT) for macrovascular complications in patients with type 2 diabetes mellitus (T2DM). Research design and methods A retrospective observational analysis was conducted involving 75 subjects with normal glucose tolerance (NGT) and 496 patients with T2DM, all of whom underwent a 3-hour OGTT, along with insulin and C-peptide release tests. Multivariate linear regression models assessed the cross-sectional associations between glucose response curve shapes and common carotid artery (CCA) diameter and intima-media thickness (IMT) in T2DM patients. Risk factors for carotid atherosclerosis analyzed using multivariate logistic regression. Results Among patients with type 2 diabetes who underwent OGTT, the group with monophasic curves (n = 282) showed higher blood glucose levels, increased insulin resistance, and poorer pancreatic β-cell function compared to the multiphasic curve group (n = 214). Larger CCA diameters were independently associated with monophasic curves compared to multiphasic curves (regression coefficient: 0.134 [0.016, 0.252], P = 0.026). Increased IMT was independently associated with monophasic curves compared to multiphase curves (regression coefficient: 0.038 [0.001, 0.075], P = 0.045). Independent risk factors for carotid atherosclerosis in T2DM patients included monophasic curve (odds ratio [OR] 2.014, 95% confidence interval [CI] 1.300-3.121, P = 0.002), age (OR 1.040, 95% CI 1.020–1.059, P < 0.001), male sex (OR 2.107, 95% CI 1.364–3.256, P = 0.001), and duration of diabetes (OR 1.043, 95% CI 1.009–1.078, P = 0.012). Conclusion The shape of the glucose response curve during OGTT was significantly linked to the risk of macrovascular complications in T2DM patients. Those with monophasic glucose curves were at an elevated risk of developing such complications. |
| format | Article |
| id | doaj-art-aee45e0dd7db4d37bb32776b603e4494 |
| institution | Kabale University |
| issn | 1758-5996 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | Diabetology & Metabolic Syndrome |
| spelling | doaj-art-aee45e0dd7db4d37bb32776b603e44942025-08-20T04:02:56ZengBMCDiabetology & Metabolic Syndrome1758-59962025-07-0117111110.1186/s13098-025-01867-6Relationship between glucose response curve shape during the oral glucose tolerance test and macrovascular complications in type 2 diabetes mellitusRong Ouyang0Han Zhang1Xiaoqin Zhao2Renyue Hu3Yi Sun4Wei Chen5Chen Qian6Yunjuan Gu7Xinlei Wang8Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong UniversityDepartment of Endocrinology and Metabolism, Affiliated Hospital of Nantong UniversityDepartment of Endocrinology and Metabolism, Affiliated Hospital of Nantong UniversityDepartment of Endocrinology and Metabolism, Affiliated Hospital of Nantong UniversityDepartment of Endocrinology and Metabolism, Affiliated Hospital of Nantong UniversityDepartment of Endocrinology and Metabolism, Affiliated Hospital of Nantong UniversityCenter of Laboratory Medicine, Affiliated Hospital of Nantong UniversityDepartment of Endocrinology and Metabolism, Affiliated Hospital of Nantong UniversityDepartment of Endocrinology and Metabolism, Affiliated Hospital of Nantong UniversityAbstract Introduction This study evaluated the predictive value of glucose response curve shape during the oral glucose tolerance test (OGTT) for macrovascular complications in patients with type 2 diabetes mellitus (T2DM). Research design and methods A retrospective observational analysis was conducted involving 75 subjects with normal glucose tolerance (NGT) and 496 patients with T2DM, all of whom underwent a 3-hour OGTT, along with insulin and C-peptide release tests. Multivariate linear regression models assessed the cross-sectional associations between glucose response curve shapes and common carotid artery (CCA) diameter and intima-media thickness (IMT) in T2DM patients. Risk factors for carotid atherosclerosis analyzed using multivariate logistic regression. Results Among patients with type 2 diabetes who underwent OGTT, the group with monophasic curves (n = 282) showed higher blood glucose levels, increased insulin resistance, and poorer pancreatic β-cell function compared to the multiphasic curve group (n = 214). Larger CCA diameters were independently associated with monophasic curves compared to multiphasic curves (regression coefficient: 0.134 [0.016, 0.252], P = 0.026). Increased IMT was independently associated with monophasic curves compared to multiphase curves (regression coefficient: 0.038 [0.001, 0.075], P = 0.045). Independent risk factors for carotid atherosclerosis in T2DM patients included monophasic curve (odds ratio [OR] 2.014, 95% confidence interval [CI] 1.300-3.121, P = 0.002), age (OR 1.040, 95% CI 1.020–1.059, P < 0.001), male sex (OR 2.107, 95% CI 1.364–3.256, P = 0.001), and duration of diabetes (OR 1.043, 95% CI 1.009–1.078, P = 0.012). Conclusion The shape of the glucose response curve during OGTT was significantly linked to the risk of macrovascular complications in T2DM patients. Those with monophasic glucose curves were at an elevated risk of developing such complications.https://doi.org/10.1186/s13098-025-01867-6Type 2 diabetes mellitusOral glucose tolerance testDiabetic macrovascular complicationsGlucose response curveCarotid atherosclerosis |
| spellingShingle | Rong Ouyang Han Zhang Xiaoqin Zhao Renyue Hu Yi Sun Wei Chen Chen Qian Yunjuan Gu Xinlei Wang Relationship between glucose response curve shape during the oral glucose tolerance test and macrovascular complications in type 2 diabetes mellitus Diabetology & Metabolic Syndrome Type 2 diabetes mellitus Oral glucose tolerance test Diabetic macrovascular complications Glucose response curve Carotid atherosclerosis |
| title | Relationship between glucose response curve shape during the oral glucose tolerance test and macrovascular complications in type 2 diabetes mellitus |
| title_full | Relationship between glucose response curve shape during the oral glucose tolerance test and macrovascular complications in type 2 diabetes mellitus |
| title_fullStr | Relationship between glucose response curve shape during the oral glucose tolerance test and macrovascular complications in type 2 diabetes mellitus |
| title_full_unstemmed | Relationship between glucose response curve shape during the oral glucose tolerance test and macrovascular complications in type 2 diabetes mellitus |
| title_short | Relationship between glucose response curve shape during the oral glucose tolerance test and macrovascular complications in type 2 diabetes mellitus |
| title_sort | relationship between glucose response curve shape during the oral glucose tolerance test and macrovascular complications in type 2 diabetes mellitus |
| topic | Type 2 diabetes mellitus Oral glucose tolerance test Diabetic macrovascular complications Glucose response curve Carotid atherosclerosis |
| url | https://doi.org/10.1186/s13098-025-01867-6 |
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