Randomized controlled study: Comparison of 20% autologous- serum eye drops with unpreserved hypromellose in the treatment of aqueous-tear- deficient dry-eye disease
Objective: This study evaluated the effectiveness of 20% autologous-serum eye drops versus unpreserved hypromellose in the treatment of patients with aqueoustear-deficient dry-eye disease. Methods: Patients fulfilling entry criteria were randomized to either 8 weeks of 20% autologous serum eye dro...
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Philippine Academy of Ophthalmology
2007-06-01
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| Series: | Philippine Journal of Ophthalmology |
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| Online Access: | https://paojournal.com/index.php/pjo/article/view/352 |
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| author | Simplicio I. Hocson III, MD Kristine T Lo, MD Ruben Lim-Bon-Siong, MD |
| author_facet | Simplicio I. Hocson III, MD Kristine T Lo, MD Ruben Lim-Bon-Siong, MD |
| author_sort | Simplicio I. Hocson III, MD |
| collection | DOAJ |
| description | Objective: This study evaluated the effectiveness of 20% autologous-serum eye drops versus unpreserved hypromellose in the treatment of patients with aqueoustear-deficient dry-eye disease.
Methods: Patients fulfilling entry criteria were randomized to either 8 weeks of 20% autologous serum eye drops or 8 weeks of unpreserved hypromellose eyedrops. Changes from baseline at 1, 2, 4, and 8-week values of corneal and conjunctival staining with fluorescein and lissamine green, tear-break-up time (TBUT), Schirmer test (with anesthesia), and ocular-surface-disease index (OSDI) were measured. Statistical analyses were carried out using analysis of variance (ANOVA) and the Bonferroni-Holm adjustment.
Results: Thirty eyes (15 patients) in the autologous-serum group and 26 eyes (13 patients) in the unpreserved-hypromellose group completed the study. Corneal staining with lissamine green (p = 0.05) and conjunctival staining with fluorescein (p = 0.04) showed significant improvement in scores in the autologous-serum group compared to that of the unpreserved hypromellose group at 2 weeks. After 8 weeks of treatment, however, differences in staining scores, Schirmer test, and TBUT were not significant. The OSDI (p = 0.002) showed significantly greater improvement in the autologous-serum group than in the unpreserved hypromellose group.
Conclusions: Use of both 20% autologous-serum eye drops andunpreserved hypromellose is safe and effective as singletreatment for aqueous-tear-deficient dry-eye disease. How-ever, dry-eye condition improved earlier among patientsin the autologous-serum group than those in theunpreserved hypromellose group, and provided greaterfunctional improvement and symptomatic relief. |
| format | Article |
| id | doaj-art-aee1a0a8d83f4f628532555f03ca9cfb |
| institution | DOAJ |
| issn | 0031-7659 |
| language | English |
| publishDate | 2007-06-01 |
| publisher | Philippine Academy of Ophthalmology |
| record_format | Article |
| series | Philippine Journal of Ophthalmology |
| spelling | doaj-art-aee1a0a8d83f4f628532555f03ca9cfb2025-08-20T02:42:08ZengPhilippine Academy of OphthalmologyPhilippine Journal of Ophthalmology0031-76592007-06-013211824352Randomized controlled study: Comparison of 20% autologous- serum eye drops with unpreserved hypromellose in the treatment of aqueous-tear- deficient dry-eye diseaseSimplicio I. Hocson III, MD0Kristine T Lo, MD1Ruben Lim-Bon-Siong, MD2Department of Ophthalmology and Visual Sciences University of the Philippines–Philippine General Hospital Manila, PhilippinesDepartment of Ophthalmology and Visual Sciences University of the Philippines–Philippine General Hospital Manila, PhilippinesDepartment of Ophthalmology and Visual Sciences University of the Philippines–Philippine General Hospital Manila, Philippines; International Eye Institute St. Luke’s Medical Center Quezon City, PhilippinesObjective: This study evaluated the effectiveness of 20% autologous-serum eye drops versus unpreserved hypromellose in the treatment of patients with aqueoustear-deficient dry-eye disease. Methods: Patients fulfilling entry criteria were randomized to either 8 weeks of 20% autologous serum eye drops or 8 weeks of unpreserved hypromellose eyedrops. Changes from baseline at 1, 2, 4, and 8-week values of corneal and conjunctival staining with fluorescein and lissamine green, tear-break-up time (TBUT), Schirmer test (with anesthesia), and ocular-surface-disease index (OSDI) were measured. Statistical analyses were carried out using analysis of variance (ANOVA) and the Bonferroni-Holm adjustment. Results: Thirty eyes (15 patients) in the autologous-serum group and 26 eyes (13 patients) in the unpreserved-hypromellose group completed the study. Corneal staining with lissamine green (p = 0.05) and conjunctival staining with fluorescein (p = 0.04) showed significant improvement in scores in the autologous-serum group compared to that of the unpreserved hypromellose group at 2 weeks. After 8 weeks of treatment, however, differences in staining scores, Schirmer test, and TBUT were not significant. The OSDI (p = 0.002) showed significantly greater improvement in the autologous-serum group than in the unpreserved hypromellose group. Conclusions: Use of both 20% autologous-serum eye drops andunpreserved hypromellose is safe and effective as singletreatment for aqueous-tear-deficient dry-eye disease. How-ever, dry-eye condition improved earlier among patientsin the autologous-serum group than those in theunpreserved hypromellose group, and provided greaterfunctional improvement and symptomatic relief.https://paojournal.com/index.php/pjo/article/view/352autologous-serum eye dropsunpreserved hypromelloseaqueous-deficiency dry-eye diseaseocular-surface stainingocular-surface-disease index |
| spellingShingle | Simplicio I. Hocson III, MD Kristine T Lo, MD Ruben Lim-Bon-Siong, MD Randomized controlled study: Comparison of 20% autologous- serum eye drops with unpreserved hypromellose in the treatment of aqueous-tear- deficient dry-eye disease Philippine Journal of Ophthalmology autologous-serum eye drops unpreserved hypromellose aqueous-deficiency dry-eye disease ocular-surface staining ocular-surface-disease index |
| title | Randomized controlled study: Comparison of 20% autologous- serum eye drops with unpreserved hypromellose in the treatment of aqueous-tear- deficient dry-eye disease |
| title_full | Randomized controlled study: Comparison of 20% autologous- serum eye drops with unpreserved hypromellose in the treatment of aqueous-tear- deficient dry-eye disease |
| title_fullStr | Randomized controlled study: Comparison of 20% autologous- serum eye drops with unpreserved hypromellose in the treatment of aqueous-tear- deficient dry-eye disease |
| title_full_unstemmed | Randomized controlled study: Comparison of 20% autologous- serum eye drops with unpreserved hypromellose in the treatment of aqueous-tear- deficient dry-eye disease |
| title_short | Randomized controlled study: Comparison of 20% autologous- serum eye drops with unpreserved hypromellose in the treatment of aqueous-tear- deficient dry-eye disease |
| title_sort | randomized controlled study comparison of 20 autologous serum eye drops with unpreserved hypromellose in the treatment of aqueous tear deficient dry eye disease |
| topic | autologous-serum eye drops unpreserved hypromellose aqueous-deficiency dry-eye disease ocular-surface staining ocular-surface-disease index |
| url | https://paojournal.com/index.php/pjo/article/view/352 |
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