Associations of Trauma Severity with Mean Platelet Volume and Levels of Systemic Inflammatory Markers (IL1β, IL6, TNFα, and CRP)
We investigated the associations of injury severity scores (ISSs) with the mean platelet volume, the serum levels of two interleukins (IL1β and IL6), and the serum levels of tumour necrosis factor-α (TNFα) and C-reactive protein (CRP). We sought to identify biochemical parameters that could be used...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/9894716 |
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| _version_ | 1832561108093763584 |
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| author | Baris Alper Baris Erdogan Mehmet Özgür Erdogan Korkut Bozan Murat Can |
| author_facet | Baris Alper Baris Erdogan Mehmet Özgür Erdogan Korkut Bozan Murat Can |
| author_sort | Baris Alper |
| collection | DOAJ |
| description | We investigated the associations of injury severity scores (ISSs) with the mean platelet volume, the serum levels of two interleukins (IL1β and IL6), and the serum levels of tumour necrosis factor-α (TNFα) and C-reactive protein (CRP). We sought to identify biochemical parameters that could be used as components of a new biochemical parameter-based ISS system. The levels of CRP, TNFα, IL1β, and IL6 differed significantly (all p values < 0.05) between severely injured patients and controls. The mean platelet volume (MPV) did not correlate with the ISSs (p > 0.05). The TNFα and IL6 levels were useful for determining the severity of injury, and the CRP level was elevated in all trauma patients but did not correlate with the ISS. The IL1β level was higher in the study group but did not increase as the ISS increased. IL6 and TNFα levels were higher in the study group and increased as the ISS increased. We found no significant difference between the trauma group and healthy individuals in terms of MPV values. IL6 and TNFα levels can be used to assess trauma severity. However, neither the MPV nor the CRP or IL1β level is useful for this purpose. |
| format | Article |
| id | doaj-art-aede0776533746fa9a5326b94083dd40 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-aede0776533746fa9a5326b94083dd402025-02-03T01:25:55ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/98947169894716Associations of Trauma Severity with Mean Platelet Volume and Levels of Systemic Inflammatory Markers (IL1β, IL6, TNFα, and CRP)Baris Alper0Baris Erdogan1Mehmet Özgür Erdogan2Korkut Bozan3Murat Can4Department of Emergency Medicine, Klinikum Fürth Zentrale Notaufnahme, 90766 Fürth, GermanyDepartment of Otolaryngology, Medipol University Healthcare and Research Center Esenler Hospital, 34230 Istanbul, TurkeyDepartment of Emergency Medicine, Haydarpasa Numune Training and Research Hospital, 34668 Istanbul, TurkeyDepartment of Emergency Medicine, Göztepe Medicalpark Hospital, 34732 Istanbul, TurkeyDepartment of Biochemistry, Bulent Ecevit University Hospital, 67600 Zonguldak, TurkeyWe investigated the associations of injury severity scores (ISSs) with the mean platelet volume, the serum levels of two interleukins (IL1β and IL6), and the serum levels of tumour necrosis factor-α (TNFα) and C-reactive protein (CRP). We sought to identify biochemical parameters that could be used as components of a new biochemical parameter-based ISS system. The levels of CRP, TNFα, IL1β, and IL6 differed significantly (all p values < 0.05) between severely injured patients and controls. The mean platelet volume (MPV) did not correlate with the ISSs (p > 0.05). The TNFα and IL6 levels were useful for determining the severity of injury, and the CRP level was elevated in all trauma patients but did not correlate with the ISS. The IL1β level was higher in the study group but did not increase as the ISS increased. IL6 and TNFα levels were higher in the study group and increased as the ISS increased. We found no significant difference between the trauma group and healthy individuals in terms of MPV values. IL6 and TNFα levels can be used to assess trauma severity. However, neither the MPV nor the CRP or IL1β level is useful for this purpose.http://dx.doi.org/10.1155/2016/9894716 |
| spellingShingle | Baris Alper Baris Erdogan Mehmet Özgür Erdogan Korkut Bozan Murat Can Associations of Trauma Severity with Mean Platelet Volume and Levels of Systemic Inflammatory Markers (IL1β, IL6, TNFα, and CRP) Mediators of Inflammation |
| title | Associations of Trauma Severity with Mean Platelet Volume and Levels of Systemic Inflammatory Markers (IL1β, IL6, TNFα, and CRP) |
| title_full | Associations of Trauma Severity with Mean Platelet Volume and Levels of Systemic Inflammatory Markers (IL1β, IL6, TNFα, and CRP) |
| title_fullStr | Associations of Trauma Severity with Mean Platelet Volume and Levels of Systemic Inflammatory Markers (IL1β, IL6, TNFα, and CRP) |
| title_full_unstemmed | Associations of Trauma Severity with Mean Platelet Volume and Levels of Systemic Inflammatory Markers (IL1β, IL6, TNFα, and CRP) |
| title_short | Associations of Trauma Severity with Mean Platelet Volume and Levels of Systemic Inflammatory Markers (IL1β, IL6, TNFα, and CRP) |
| title_sort | associations of trauma severity with mean platelet volume and levels of systemic inflammatory markers il1β il6 tnfα and crp |
| url | http://dx.doi.org/10.1155/2016/9894716 |
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