Simultaneous and Rapid Determination of Six Tyrosine Kinase Inhibitors in Patients with Non-Small Cell Lung Cancer Using HPLC-MS/MS

Simultaneous and Rapid Determination of Six Tyrosine Kinase Inhibitors in Patients with Non-Small Cell Lung Cancer Using HPLC-MS/MS

Objective. To develop a new method for quantitatively analyzing six tyrosine kinase inhibitors (gefitinib, erlotinib, icotinib, afatinib, osimertinib, and crizotinib) used in the treatment of non-small cell lung cancer (NSCLC) by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Methods. Th...

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Bibliographic Details
Main Authors: Yanping Liu, Hua Liu, Zhewei Xia, Zhipeng Wang, Yunlei Yun, Guanying Zhang, Lifeng Huang, Shouhong Gao, Wansheng Chen
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:International Journal of Analytical Chemistry
Online Access:http://dx.doi.org/10.1155/2021/5524361
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